THE ROLE OF LEUKOCYTE AND PLATELET-RICH FIBRIN IN THE PREVENTION OF MEDICATION-RELATED OSTEONECROSIS OF THE JAW, IN PATIENTS REQUIRING DENTAL EXTRACTIONS: AN OBSERVATIONAL STUDY
Authors:
Panagiotis Pitros
Affiliation:
Edinburgh Dental Institute University of Edinburgh, Edinburgh, United Kingdom
Doi: 10.54936/haoms242p89
ABSTRACT:
Abstract: Objectives: Medication-related osteonecrosis of the jaw (MRONJ) is a significant complication which can present following a dental extraction in patients receiving anti-resorptive and anti-angiogenic medications. The purpose of this study was to investigate the possible beneficial effect of L-PRF in the prevention of MRONJ in patients receiving these medications and requiring dental extractions.
Materials and Methods: Thirty-nine patients were included and divided in two groups, depending on whether L-PRF was used after the required dental extraction or not. Subsequently, the patients were categorised into low and high-risk for developing MRONJ, as recommended by the Scottish Dental Clinical Effectiveness Programme (SDCEP) guidance.
Results: None of the patients in the L-PRF group returned with established MRONJ. Five high-risk patients in the control group presented with established MRONJ in the follow-up appointment. Significant statistical difference (p=0.04) was observed following comparison of the high-risk patients of the two groups.
Conclusion: These encouraging results suggest that L-PRF may be useful in the prevention of MRONJ following a dental extraction especially in patients of the higher risk category. A protocol for the management of this type of patients is also introduced.
KEY WORDS: Medication-related osteonecrosis of the jaw; Leukocyte and Platelet-rich fibrin; Dental extraction; Oral Pathology; Bisphosphonates
Authors:
Panagiotis Pitros
Affiliation:
Edinburgh Dental Institute University of Edinburgh, Edinburgh, United Kingdom
Doi: 10.54936/haoms242p89
ABSTRACT:
Abstract: Objectives: Medication-related osteonecrosis of the jaw (MRONJ) is a significant complication which can present following a dental extraction in patients receiving anti-resorptive and anti-angiogenic medications. The purpose of this study was to investigate the possible beneficial effect of L-PRF in the prevention of MRONJ in patients receiving these medications and requiring dental extractions.
Materials and Methods: Thirty-nine patients were included and divided in two groups, depending on whether L-PRF was used after the required dental extraction or not. Subsequently, the patients were categorised into low and high-risk for developing MRONJ, as recommended by the Scottish Dental Clinical Effectiveness Programme (SDCEP) guidance.
Results: None of the patients in the L-PRF group returned with established MRONJ. Five high-risk patients in the control group presented with established MRONJ in the follow-up appointment. Significant statistical difference (p=0.04) was observed following comparison of the high-risk patients of the two groups.
Conclusion: These encouraging results suggest that L-PRF may be useful in the prevention of MRONJ following a dental extraction especially in patients of the higher risk category. A protocol for the management of this type of patients is also introduced.
KEY WORDS: Medication-related osteonecrosis of the jaw; Leukocyte and Platelet-rich fibrin; Dental extraction; Oral Pathology; Bisphosphonates