cGVHD AND BIOMARKERS RESEARCH IN HUMAN HISTOPATHOLOGIC SAMPLES FROM ORAL MUCOSA
Authors:
Vaia-Aikaterini Alexoudi, Alexandros Louizakis, Gavrilaki Eleni, Stavroula Papadopoulou, Konstantinos Vahtsevanos
Affiliation:
General Hospital of Thessaloniki “Papanikolaou”, Thessaloniki, Greece
Doi: 10.54936/haoms242p05
ABSTRACT:
Objectives: Chronic graft versus host disease (cGVHD) is a major cause of morbidity and mortality in allogeneic hematopoietic cell transplant (alloHCT) patients. Consensus criteria have been developed taking into account histopathologic samples of the oral mucosa which is accessible for routine biopsy, in order to guide diagnostic and treatment decisions for cGVHD.
The biopsies of the oral mucosa demonstrate mostly periductal lymphocyte infiltration, fibroplasia and mixed lymphocytic and plasmacytic inflammation. Nonetheless there are no up-to-date validated biomarkers in order to assess an early diagnosis and earlier treatment for HCT patients. This study aims to search for biomarkers in samples of the oral mucosa or minor salivary glands and in blood samples and finally to assess the quality of life in these patients.
KEY WORDS: cGVHD, oral mucosa, biomarkers
Authors:
Vaia-Aikaterini Alexoudi, Alexandros Louizakis, Gavrilaki Eleni, Stavroula Papadopoulou, Konstantinos Vahtsevanos
Affiliation:
General Hospital of Thessaloniki “Papanikolaou”, Thessaloniki, Greece
Doi: 10.54936/haoms242p05
ABSTRACT:
Objectives: Chronic graft versus host disease (cGVHD) is a major cause of morbidity and mortality in allogeneic hematopoietic cell transplant (alloHCT) patients. Consensus criteria have been developed taking into account histopathologic samples of the oral mucosa which is accessible for routine biopsy, in order to guide diagnostic and treatment decisions for cGVHD.
The biopsies of the oral mucosa demonstrate mostly periductal lymphocyte infiltration, fibroplasia and mixed lymphocytic and plasmacytic inflammation. Nonetheless there are no up-to-date validated biomarkers in order to assess an early diagnosis and earlier treatment for HCT patients. This study aims to search for biomarkers in samples of the oral mucosa or minor salivary glands and in blood samples and finally to assess the quality of life in these patients.
KEY WORDS: cGVHD, oral mucosa, biomarkers