Paediatric mucoepidermoid carcinoma of the palate Case report
Nikolaos PAPADOGEORGAKIS, Nikolaos NIKITAKIS, Dionisios FOTOPOULOS, Alexandra SKLAVOUNOU, Constantinos ALEXANDRIDIS
University Clinic of Oral and Maxillofacial Surgery, Dental School, University of Athens, “Evangelismos” Hospital, Greece (Head: Prof. C. Alexandridis) Department of Oral Pathology, Dental School, University of Athens, Greece (Head: Prof. A. Sklavounou)
Hellenic Archives of Oral & Maxillofacial Surgery (2011) 1, 27-35
SUMMARY: Μucoepidermoid carcinoma although being the most frequent type of malignant salivary gland neoplasm, it rarely affects children. A 15-year-old boy initially presented with a painless swelling located on the border between the hard and soft palate, on the right side of the middle line. This swelling had been discovered by the referring dentist one month ago. Overlying mucosa was normal, bluish in colour. The neoplasm was 1.5 cm and had a fluctuating composition. The partial biopsy that was performed revealed a well-differentiated mucoepidermoid carcinoma. The patient underwent a complete clinical, laboratory and imaging examination followed by complete excision of the tumour. Histological examination of the surgical specimen confirmed the initial diagnosis. During a follow-up period of 1.5 years there was no recurrence. Although they rarely occur in children, malignant neoplasms of the minor salivary glands should be included in the differential diagnosis of oral tumours, especially if these tumours are located on the border between the hard and soft palate.
KEY WORDS: Salivary gland tumours, mucoepidermoid carcinoma, childhood.
REFERENCES
Αγγελόπουλος Α, Παπανικολάου Σ, Αγγελοπούλου Ε: Σύγχρονη Στοματική και Γναθοπροσωπική Παθολογία. Ιατρικές Εκδόσεις Λίτσας. 3η Εκδ. 2000. σελ. 305-8.
Αγγελόπουλος Α, Αλεξανδρίδης Κ: Σύγχρονη Στοματική και Γναθοπροσωπική Χειρουργική. Εκδ. Αγγελόπουλος. 2004 σελ. 715-18.
Auclair PL, Goode RK, Ellis GL: Mucoepidermoid carcinoma of intraoral salivary glands. Evaluation and application of grading criteria 143 cases. Cancer 69(8): 2021-30, 1992 Baker SR, Malone B: Salivary gland malignancies in children. Cancer 55(8): 1730-6. 1985
Batsakis JG: Salivary gland neoplasia: an outcome of modified morphogenesis and cyttodifferentiation. Oral Surg Oral Med Oral Pathol. 49(3): 229-32. 1980 Bradley P, McClelland L, Mehta D: Pediatric salivary gland epithelial neoplasms. ORL J Otorhinolaryngol Relat Spec. 69 (3): 137-45, 2007
Caccamese JF, Ord RA: Paediatric mucoepidermoid carcinoma of the palate. Int J Oral Maxillofac Surg 31(2): 136-9. 2002
Callender DL, Frankenthaler RA, Luna MA, Lee SS, Goepfert H: Salivary gland neoplasms in children. Arch Otolaryngol Head Neck Surg 118(5): 472-6. 1992 Conley J, Tinsley PP: Treatment and prognosis of mucoepidermoid carcinoma in the pediatric age group. Arch Otolaryngol 111(5): 322-4. 1985
Ellies M, Laskawi R, Arglebe C, Scott A: Surgical management of nonneoplastic diseases of the submandibular gland. Int J Oral Maxillofac Surg. 25: 285-289. 2006
Ethunandan M, Ethumandan A, Macpherson D, Conroy B, Pratt C: Parotid neoplasms in children : experience of diagnosis and management in a district general hospital. Int J Oral Maxillofac Surg 32: 373-7. 2003
Guzzo M, Ferrari A, Marcon I: Salivary gland neoplasms in children. The experience of the Instituto Nationale Tumori of Milan. Pediatric Βlood Cancer 47: 806. 2006
Hicks MJ, el Naggar AK, Flaitz CM, Luna MA, Batsakis JG: Histo - cytologic grading of mucoepidermoid carcinoma of major salivary glands in prognosis and survival: a clinicopathologic and flow cytometric investigation. Head Neck 17(2): 89-95, 1995
Hicks J, Flaitz C: Mucoepidermoid carcinoma of salivary glands in children and adolescents: assessment of proliferation markers. Oral Oncology. 36(5): 454-60, 2000
Ιατρού Ι, Αγγελόπουλος Α, Αλεξανδρίδης Κ: Στην Σύγχρονη Στοματική και Γναθοπροσωπική Χειρουργική. Στοματική και Γναθοπροσωπική Χειρουργική σε Παιδιά. Έκδοση 2004. σελ. 980-3.
Kessler A, Handler SD: Salivary gland neoplasms in children: a 10 years survey at The Children’s Hospital of Philadelphia. Int Journal of Pediatric Otorhinolaryngology. 29: 195-202, 1994
Laikui L, Hongewi L, Hongbing J, Zhixiu H: Epithelial salivary gland tumors of children and adolescents in west China population: a clinicopathologic study of 79 cases. J Oral Pathol Med 37(4): 201-5, 2008
Nagano T, Caffey TA, Olsen KD, Serizawa H, Lewis JE: Small cell carcinoma of the major salivary glands: a cliniclpathologic study with emphasis on cytokeratin 20 immunoreactivity and clinical outcome. Am Surg Pathol 28:769-70, 2004
Olsen KD, Devine KD, Weilland LH: Mucoepideermoid carcinoma of the oral cavity. Otolaryngol Head Neck Surg 89(5): 783-91, 1981
Orvidas LJ, kasperbauer JL, Lewis JF,Olsen KD, Lesnik TG: Pediatric parotid mass. Arch Otolaryngol Head Neck Surg 126(2): 177- 84, 2000
Papadogeorgakis N, Goutzanis L, Marti K, Koutselini E, Gorgis G, Aggelopoulos A: The diagnostic value of FNA in parotid tumors. Hellenic Arch Oral Maxillofac Surg 1(4): 313-18, 2000
Perez DE, Pires FR, Alves Fde, Lopes MA, de Almeida OP, Kowalski LP: Salivary gland tumors in children and adolescent a clinicopathologic and immunohistochemical study of fifty three cases. Int J Pediatric Otolaryngology 68: 895-902, 2004
Perez DE, Pires FR, Alves FdeA, Lopes MA, de Almeida OP, Kowalski LP: Juvenile Intraoral mucoepidermoid carcinoma. J Oral Maxillofac Surg 66 (2): 308-11, 2008
Perez FR , de Almeida OP, Alves FdeA, Kowalski LP: Prognostic factors in head and neck mucoepidermoid carcinoma. Arch Otolaryngol Head Neck Surg 130: 174-180, 2004
Rehbar R, Grimmer F, Vargas SO, Robson CD, Mack J W, PerezAtayde AR, Marcus KJ, Grier HE, Healy GB, McGill TJ: Mucoepidermoid Carcinoma of the parotid gland in children. A 10 – year experience. Arch Otolaryngol Head Neck Surg132(4): 375-80, 2006
Rogers DA, Rao BN, Bowman L, Marina N, Fleming ID, Schropp KP, Lobe TE: Primary malignancy of the salivary gland in children. J Pediatr Surg 29(1):44-7, 1994
Seifert G, Okabe H, Caselitz J: Epithelial salivary gland tumors in children and adolescents. Analysis of 80 cases (Salivary Gland Register 1965-1984). ORL J Otorhinolaryngol Relat Spec. 48(3):137-49, 1986
Shikhani AH, Johns ME: Tumors of the major salivary glands in children. Head Neck Surg 10 (4): 257-63, 1988
Sismanis A, Merriam JM, Kline TS, Davis RK, Shapshay SM, Strong MS: Diagnosis of salivary gland tumors by fine needle aspiration biopsy. Head Neck Surg 3(6): 482-9, 1981
Stewart FW, Foote FW, Becker WF: Mucoepidermoid tumors of salivary glands. Ann Surg 122: 820-44, 1945
Toida M, Shimokawa K, Makita H, Kato K, Kobayashi A, Kusunoki Y, Hatakeyama D, Fujitsuka H, Yamashita T, Shibata T: Intraoral minor salivary gland tumors: a clinicopathological study of 82 cases. Int J Oral Maxillofacial Surg 34(5): 528-32, 2005
Vedrine PO, Coffinet L, Temam S, Montagne K, Lapeyre M, Oberlin O, Orbach D, Simon C, Sommelet D: Mucoepidermoid carcinoma of salivary glands in the pediatric age group: 18 clinical cases, including 11 second malignant neoplasms. Head and Neck Surg 28 (9): 827-33, 2006
Weber RS, Byers RM, Petit B, Wolf P, Ang K, Luna M: Submandibular gland tumors. Adverse histologic factors and therapeutic implications. Arch Otolaryngol Head Neck Surg 116(9):1055-60, 1990
University Clinic of Oral and Maxillofacial Surgery, Dental School, University of Athens, “Evangelismos” Hospital, Greece (Head: Prof. C. Alexandridis) Department of Oral Pathology, Dental School, University of Athens, Greece (Head: Prof. A. Sklavounou)
Hellenic Archives of Oral & Maxillofacial Surgery (2011) 1, 27-35
SUMMARY: Μucoepidermoid carcinoma although being the most frequent type of malignant salivary gland neoplasm, it rarely affects children. A 15-year-old boy initially presented with a painless swelling located on the border between the hard and soft palate, on the right side of the middle line. This swelling had been discovered by the referring dentist one month ago. Overlying mucosa was normal, bluish in colour. The neoplasm was 1.5 cm and had a fluctuating composition. The partial biopsy that was performed revealed a well-differentiated mucoepidermoid carcinoma. The patient underwent a complete clinical, laboratory and imaging examination followed by complete excision of the tumour. Histological examination of the surgical specimen confirmed the initial diagnosis. During a follow-up period of 1.5 years there was no recurrence. Although they rarely occur in children, malignant neoplasms of the minor salivary glands should be included in the differential diagnosis of oral tumours, especially if these tumours are located on the border between the hard and soft palate.
KEY WORDS: Salivary gland tumours, mucoepidermoid carcinoma, childhood.
REFERENCES
Αγγελόπουλος Α, Παπανικολάου Σ, Αγγελοπούλου Ε: Σύγχρονη Στοματική και Γναθοπροσωπική Παθολογία. Ιατρικές Εκδόσεις Λίτσας. 3η Εκδ. 2000. σελ. 305-8.
Αγγελόπουλος Α, Αλεξανδρίδης Κ: Σύγχρονη Στοματική και Γναθοπροσωπική Χειρουργική. Εκδ. Αγγελόπουλος. 2004 σελ. 715-18.
Auclair PL, Goode RK, Ellis GL: Mucoepidermoid carcinoma of intraoral salivary glands. Evaluation and application of grading criteria 143 cases. Cancer 69(8): 2021-30, 1992 Baker SR, Malone B: Salivary gland malignancies in children. Cancer 55(8): 1730-6. 1985
Batsakis JG: Salivary gland neoplasia: an outcome of modified morphogenesis and cyttodifferentiation. Oral Surg Oral Med Oral Pathol. 49(3): 229-32. 1980 Bradley P, McClelland L, Mehta D: Pediatric salivary gland epithelial neoplasms. ORL J Otorhinolaryngol Relat Spec. 69 (3): 137-45, 2007
Caccamese JF, Ord RA: Paediatric mucoepidermoid carcinoma of the palate. Int J Oral Maxillofac Surg 31(2): 136-9. 2002
Callender DL, Frankenthaler RA, Luna MA, Lee SS, Goepfert H: Salivary gland neoplasms in children. Arch Otolaryngol Head Neck Surg 118(5): 472-6. 1992 Conley J, Tinsley PP: Treatment and prognosis of mucoepidermoid carcinoma in the pediatric age group. Arch Otolaryngol 111(5): 322-4. 1985
Ellies M, Laskawi R, Arglebe C, Scott A: Surgical management of nonneoplastic diseases of the submandibular gland. Int J Oral Maxillofac Surg. 25: 285-289. 2006
Ethunandan M, Ethumandan A, Macpherson D, Conroy B, Pratt C: Parotid neoplasms in children : experience of diagnosis and management in a district general hospital. Int J Oral Maxillofac Surg 32: 373-7. 2003
Guzzo M, Ferrari A, Marcon I: Salivary gland neoplasms in children. The experience of the Instituto Nationale Tumori of Milan. Pediatric Βlood Cancer 47: 806. 2006
Hicks MJ, el Naggar AK, Flaitz CM, Luna MA, Batsakis JG: Histo - cytologic grading of mucoepidermoid carcinoma of major salivary glands in prognosis and survival: a clinicopathologic and flow cytometric investigation. Head Neck 17(2): 89-95, 1995
Hicks J, Flaitz C: Mucoepidermoid carcinoma of salivary glands in children and adolescents: assessment of proliferation markers. Oral Oncology. 36(5): 454-60, 2000
Ιατρού Ι, Αγγελόπουλος Α, Αλεξανδρίδης Κ: Στην Σύγχρονη Στοματική και Γναθοπροσωπική Χειρουργική. Στοματική και Γναθοπροσωπική Χειρουργική σε Παιδιά. Έκδοση 2004. σελ. 980-3.
Kessler A, Handler SD: Salivary gland neoplasms in children: a 10 years survey at The Children’s Hospital of Philadelphia. Int Journal of Pediatric Otorhinolaryngology. 29: 195-202, 1994
Laikui L, Hongewi L, Hongbing J, Zhixiu H: Epithelial salivary gland tumors of children and adolescents in west China population: a clinicopathologic study of 79 cases. J Oral Pathol Med 37(4): 201-5, 2008
Nagano T, Caffey TA, Olsen KD, Serizawa H, Lewis JE: Small cell carcinoma of the major salivary glands: a cliniclpathologic study with emphasis on cytokeratin 20 immunoreactivity and clinical outcome. Am Surg Pathol 28:769-70, 2004
Olsen KD, Devine KD, Weilland LH: Mucoepideermoid carcinoma of the oral cavity. Otolaryngol Head Neck Surg 89(5): 783-91, 1981
Orvidas LJ, kasperbauer JL, Lewis JF,Olsen KD, Lesnik TG: Pediatric parotid mass. Arch Otolaryngol Head Neck Surg 126(2): 177- 84, 2000
Papadogeorgakis N, Goutzanis L, Marti K, Koutselini E, Gorgis G, Aggelopoulos A: The diagnostic value of FNA in parotid tumors. Hellenic Arch Oral Maxillofac Surg 1(4): 313-18, 2000
Perez DE, Pires FR, Alves Fde, Lopes MA, de Almeida OP, Kowalski LP: Salivary gland tumors in children and adolescent a clinicopathologic and immunohistochemical study of fifty three cases. Int J Pediatric Otolaryngology 68: 895-902, 2004
Perez DE, Pires FR, Alves FdeA, Lopes MA, de Almeida OP, Kowalski LP: Juvenile Intraoral mucoepidermoid carcinoma. J Oral Maxillofac Surg 66 (2): 308-11, 2008
Perez FR , de Almeida OP, Alves FdeA, Kowalski LP: Prognostic factors in head and neck mucoepidermoid carcinoma. Arch Otolaryngol Head Neck Surg 130: 174-180, 2004
Rehbar R, Grimmer F, Vargas SO, Robson CD, Mack J W, PerezAtayde AR, Marcus KJ, Grier HE, Healy GB, McGill TJ: Mucoepidermoid Carcinoma of the parotid gland in children. A 10 – year experience. Arch Otolaryngol Head Neck Surg132(4): 375-80, 2006
Rogers DA, Rao BN, Bowman L, Marina N, Fleming ID, Schropp KP, Lobe TE: Primary malignancy of the salivary gland in children. J Pediatr Surg 29(1):44-7, 1994
Seifert G, Okabe H, Caselitz J: Epithelial salivary gland tumors in children and adolescents. Analysis of 80 cases (Salivary Gland Register 1965-1984). ORL J Otorhinolaryngol Relat Spec. 48(3):137-49, 1986
Shikhani AH, Johns ME: Tumors of the major salivary glands in children. Head Neck Surg 10 (4): 257-63, 1988
Sismanis A, Merriam JM, Kline TS, Davis RK, Shapshay SM, Strong MS: Diagnosis of salivary gland tumors by fine needle aspiration biopsy. Head Neck Surg 3(6): 482-9, 1981
Stewart FW, Foote FW, Becker WF: Mucoepidermoid tumors of salivary glands. Ann Surg 122: 820-44, 1945
Toida M, Shimokawa K, Makita H, Kato K, Kobayashi A, Kusunoki Y, Hatakeyama D, Fujitsuka H, Yamashita T, Shibata T: Intraoral minor salivary gland tumors: a clinicopathological study of 82 cases. Int J Oral Maxillofacial Surg 34(5): 528-32, 2005
Vedrine PO, Coffinet L, Temam S, Montagne K, Lapeyre M, Oberlin O, Orbach D, Simon C, Sommelet D: Mucoepidermoid carcinoma of salivary glands in the pediatric age group: 18 clinical cases, including 11 second malignant neoplasms. Head and Neck Surg 28 (9): 827-33, 2006
Weber RS, Byers RM, Petit B, Wolf P, Ang K, Luna M: Submandibular gland tumors. Adverse histologic factors and therapeutic implications. Arch Otolaryngol Head Neck Surg 116(9):1055-60, 1990
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