Immunohistochemical evaluation of transforming growth factor (TGF-b1) in
malignant salivary gland tumours
Dionisios FOTOPOULOS, Nikolaos PAPADOGEORGAKIS, Ioannis IATROU, Sofia TSELENI, Alexandra SKLAVOUNOU, Constantinos ALEXANDRIDIS
Oral & Maxillofacial Surgery Clinic, School of Dentistry, University of Athens (Head: Professor C. Αlexandridis) Oral Pathology Laboratory, School of Dentistry, University of Athens (Head: Professor A. Sklavounou)
Hellenic Archives of Oral & Maxillofacial Surgery (2011) 1, 1-14
SUMMARY: The development of malignant tumours is defined by interactions between tumour cells and the stroma through cell membrane proteins and the re - lease of cytokines. Ιt has been indicated that high concentrations of transforming growth factor (TGF-b1) in aggressive tu mours of the breast, prostate etc. can promote carcinogenesis. Aim: The aim of this study is to examine TGF-b1 expression in malignant salivary gland tumours and correlate it with clinical parameters. Material and methods: 54 specimens of malignant salivary gland tumours obtained between 1996 and 2008 (12 years) were the material of the study. 54 cases were evaluated 29 male and 25 female, 16-75 years of age. Results: TGF-b1 expression was weak and focal, located in neoplastic cells, as well as in the stroma. A positive correlation to tumour staging was also detected. Conclusions: TGF-b1 expression in malignant salivary gland tumours and its positive correlation with tumour staging provide a useful basis for the further investigation of its potential role as a prognostic index.
KEY WORDS: Transforming Growth Factor (TGF-b1), epithelial-mesenchymal transitions, malignant salivary gland tumours.
REFERENCES
Allred DC, Clark GM, Elledge R, Fuqua SA, Brown RW, Chamness GC, Osborne CK, McGuire WL: Association of p53 protein expression with tumor cell proliferation rate and clinical outcome in node-negative breast cancer. J Nat Cancer Inst 85: 200- 206, 1993
Arias MA: Epithelial Mesenchymal Interactions in Cancer and development. Cell 105: 425-31, 2001
Ariztia E, Subbarao V, Solt D, Rademaker A, Iyer A: Osteopontin contributes to hepatocyte growth factor-induced tumor growth and metastasis formation. Exper Cell Research 288(2): 257-67, 2003
Bakin A, Rinehart C: p38 mitogen activated protein kinase is required for TGF-b mediated fibroblastic transdifferentiation and cell migration. J Cell Sci 115(15): 3193-206, 2002
Barnes L, Evanson J, Reichart P, Sidransky D: World Health Organization Classification of Tumours. Pathology and genetics of head and neck tumors. IARC Press Lyon 2005, pp 210
Chioni AM, Grose R: Organotypic modelling as a means of investigating epithelial stroma interactions during tumourigenesis. Fibrogenesis and Tissue Repair, Published online (1):8, 2008
Coppola D, Szabo M, Boulware D, Muraca P, Alsarraj M, Chambers A, Yeatman T: Correlation of osteopontin protein expression and pathological stage across a wide variety of tumor histologies. Clin Cancer Research 10:184-190, 2004
Derynck R, Zhang E: Smad dependent and Smad independent pathways in TGF-b family signaling. Nature 425(6958): 577-84, 2003
Desruisseau S, Palmari C, Giusti C, Romain S, Martin P, Berthois Y: Determination of TGF-b1 protein level in human primary breast cancers and relationship with survival. British J of Cancer. 94: 239-46, 2006
Dillard DG, Muller S, Cohen C, Bloch D, Del Gaudio JM, Gal A: High tumor grade in salivary gland mucoepidermoid carcinomas and loss of expression of transforming growth factor beta receptor type II. Arch Otolaryngol Head Neck Surg 127(6): 683-6, 2001
Dumont N, Artega CL: Transforming growth factor-beta and breast cancer: tumor promoting effects of transforming growth factorβ. Breast Cancer Res 2. 125-132,2000
Figueroa J, Flanders K, Garcia Closas M, Anderson W, Yang X, Matsumo R, Duggan M, Pfeifer R, Sherman M: Expression of TGF-b signaling factors in invasive breast cancer: relationships with age at diagnosis and tumor characteristics. Breast Cancer Res Treatm 24 (11): 211-300, 2009
Ghellal A, Li C, Hayers M; Prognostic significance of TGF-b1 and TGF-b3 in human breast carcinoma. Anticancer Res 20: 4413- 18, 2000
Gorsch SΜ, Memoli VΑ, Stukel ΤΑ, Gold LΙ, Arrick ΒΑ: Immu - nohistochemical staining for transforming growth factor beta 1 associates with disease progression in human breast cancer. Cancer Res 52: 6949-6952, 1992
Grady W: Transforming growth factor-b, Smads and cancer. Clin Cancer Res 11. (9): 3151-3154, 2005
Guarino M: Epithelial mesenchymal transition and tumor invasion. Int J Biochem & Cell Biology 39: 2153-2160, 2007
Guo F, Jiang XC, Cheng RX: Expression of TGF-b1 and TGF bRI proteins in tissues of salivary adenoid cystic carcinoma. Human Yi Ke Da Xue Bao 28; 27 (3): 229-32, 2002
Heldin HC, Landstrom M, Moustakas A: Mechanism of TGF-b to growth arrest, apoptosis, and epithelial- mesenchymal transition. Current Op Cell Biology 21: 166-176, 2009
Hosmer, David W. Stanley Lemeshow: Applied Logistics Regression. 2nd Ed. New York; Chichester, Wiley 2000, pp 226-30
Markowitz SD, Roberts AB: Tumor suppressor activity of the TGF-b pathway in human cancers. Cytokine Growth Factor Rev 7(1): 93-102, 1996
Matsumoto K, Nakamura T: Hepatocyte growth factor and the Met system as a mediator of tumor stroma interactions. Int J Cancer 119: 477-483, 2006 Moustakas A, Souchelyntskyi S, Heldin C: Smad regulation in TGF-b signal trasduction. J Cell Sci 114: 4359-4369, 2001
Pollard J: Tumor stroma interactions. Transforming growth factor-b isoforms and hypatocyte growth factor/ scatter factor in mammary gland ductal morphogenesis. Breast Cancer Research 3: 230-37, 2001
Rosmary A, Dearing W, Dearing S: Transforming growth factor beta 1 in ductal carcinoma in situ and invasive carcinomas of the breast. Eur J Cancer 28(2/3): 641-44, 1992
Spiro RH, Thaler HT, Hicks WF, Kher UA, Huvos AH, Strong EW: The importance of clinical staging of minor salivary gland carcinoma. Am J Surg. 162: 330-6, 1991
Walker RA, Dearing SJ: Transforming growth factor beta 1 in ductal carcinoma in situ and invasive carcinomas of the breast. Eur J Cancer 28:641-644, 1992 Wilkstrom P, Stattin P, Frank-Lissbrant I, Damber J, Berg A: Trans - forming growth factor-b1 is associated with angiogenesis, metastasis and poor clinical outcome in prostate cancer. The Prostate 37: 19-29, 1998
Zigrino P, Loffek S, Mauch C: Tumor stroma interactions: their role in the control of tumor cell invasion. Biochimie 87: 321-328, 2004
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