MESENCHYMAL STEM CELLS IN MRONJ TREATMENT: POTENTIAL APPLICATIONS AND PROMISING REGENERATIVE THERAPIES
Authors:
Alexandros Mavros1, Christina Tsirigoni2, Zoe Nicolaou3
Affiliation:
1 DDS MSc, Edinburgh, United Kingdom
2 DDS, Edinburgh, United Kingdom
3 Director, Cyprus Cranio Maxillo Facial Center, Limassol, Cyprus
Doi: 10.54936/haoms242p06
ABSTRACT:
Objectives: HMedication-Related Osteonecrosis of the Jaw (MRONJ) is a condition causing jawbone tissue necrosis, often linked to anti-resorptive and anti-angiogenic medications. Regenerative therapies have emerged as potential treatments, with mesenchymal stem cells (MSCs) gaining attention due to their regenerative and immunomodulatory properties. MSCs exert therapeutic effects through paracrine activity, immunomodulation, and bone-forming cell differentiation. Their secreted factors promote tissue regeneration, reduce inflammation, and enhance angiogenesis. This poster summarizes MSCs’ potential applications in MRONJ treatment.
KEY WORDS: Medication-Related Osteonecrosis of the Jaw, MRONJ, mesenchymal stem cells, regenerative therapy
Authors:
Alexandros Mavros1, Christina Tsirigoni2, Zoe Nicolaou3
Affiliation:
1 DDS MSc, Edinburgh, United Kingdom
2 DDS, Edinburgh, United Kingdom
3 Director, Cyprus Cranio Maxillo Facial Center, Limassol, Cyprus
Doi: 10.54936/haoms242p06
ABSTRACT:
Objectives: HMedication-Related Osteonecrosis of the Jaw (MRONJ) is a condition causing jawbone tissue necrosis, often linked to anti-resorptive and anti-angiogenic medications. Regenerative therapies have emerged as potential treatments, with mesenchymal stem cells (MSCs) gaining attention due to their regenerative and immunomodulatory properties. MSCs exert therapeutic effects through paracrine activity, immunomodulation, and bone-forming cell differentiation. Their secreted factors promote tissue regeneration, reduce inflammation, and enhance angiogenesis. This poster summarizes MSCs’ potential applications in MRONJ treatment.
KEY WORDS: Medication-Related Osteonecrosis of the Jaw, MRONJ, mesenchymal stem cells, regenerative therapy