MEDICATION-RELATED OSTEONECROSIS OF THE JAWS. A SINGLE-CENTRE RETROSPECTIVE STUDY
Authors:
Asterios Antoniou1, Dimitris Tatsis2, Alexandros Louizakis1, Ioanna Kalaitsidou3, Ioannis Aetopoulos1, Athanassios Kyrgidis1, Konstantinos Paraskevopoulos1, Konstantinos Vachtsevanos1
Affiliation:
1 Department of Oral and Maxillofacial Surgery Aristotle University of Thessaloniki,, Thessaloniki, Greece
2 University College London Hospitals NHS Trust, United Kingdom
3 Inselspital, Universitätsspital Bern
Doi: 10.54936/haoms242p59
ABSTRACT:
Abstract: Objectives: Medication-related osteonecrosis of the jaws (MRONJ) is a serious complication of bone antiresorptive and other targeted treatment. The aim of this study is to elucidate the results of prompt surgical intervention in patients presenting with MRONJ.
Materials and Methods: In this retrospective cohort study patients with MRONJ treated in a 10-year period in a single centre were included. Demographic parameters, co-morbidities, antiresorptive treatments, stage of osteonecrosis and the surgical treatment were recorded.
Results: A total of 168 patients with a mean age of 68.5 years and a female predominance (58.3%) were included in the study. Precipitating factors of osteonecrosis, as dental trauma was recorded and represented a 72.2%. The surgical therapy included debridement or/and extensive removal of necrotic bone either from maxilla or the mandible and applied in all patients irrespectively of the staging. The distribution of MRONJ staging in the sample was 19.1% patients in stage I, 59.2% patients in stage II and 21.7% patients in stage III. Closure of the surgical defect performed in all the cases with mucoperiosteal flap and in selected cases with local flaps. Second operation was required in 20.1% of the patients.
Conclusions: The surgical of MRONJ appears to be moderately successful in a high percentage of patients, yielding complete healing or sub-staging of osteonecrosis.
KEY WORDS:
Authors:
Asterios Antoniou1, Dimitris Tatsis2, Alexandros Louizakis1, Ioanna Kalaitsidou3, Ioannis Aetopoulos1, Athanassios Kyrgidis1, Konstantinos Paraskevopoulos1, Konstantinos Vachtsevanos1
Affiliation:
1 Department of Oral and Maxillofacial Surgery Aristotle University of Thessaloniki,, Thessaloniki, Greece
2 University College London Hospitals NHS Trust, United Kingdom
3 Inselspital, Universitätsspital Bern
Doi: 10.54936/haoms242p59
ABSTRACT:
Abstract: Objectives: Medication-related osteonecrosis of the jaws (MRONJ) is a serious complication of bone antiresorptive and other targeted treatment. The aim of this study is to elucidate the results of prompt surgical intervention in patients presenting with MRONJ.
Materials and Methods: In this retrospective cohort study patients with MRONJ treated in a 10-year period in a single centre were included. Demographic parameters, co-morbidities, antiresorptive treatments, stage of osteonecrosis and the surgical treatment were recorded.
Results: A total of 168 patients with a mean age of 68.5 years and a female predominance (58.3%) were included in the study. Precipitating factors of osteonecrosis, as dental trauma was recorded and represented a 72.2%. The surgical therapy included debridement or/and extensive removal of necrotic bone either from maxilla or the mandible and applied in all patients irrespectively of the staging. The distribution of MRONJ staging in the sample was 19.1% patients in stage I, 59.2% patients in stage II and 21.7% patients in stage III. Closure of the surgical defect performed in all the cases with mucoperiosteal flap and in selected cases with local flaps. Second operation was required in 20.1% of the patients.
Conclusions: The surgical of MRONJ appears to be moderately successful in a high percentage of patients, yielding complete healing or sub-staging of osteonecrosis.
KEY WORDS: