MICRO-RNAS IN ORAL SQUAMOUS CELL CARCINOMA: A NARRATIVE UPDATE ON CURRENT CONCEPTS
Authors:
Chrysostomidis A., Politis S., Koloutsos G., Astreidis I., Paraskevopoulos K., Vahtsevanos K.
Affiliation:
Oral Maxillofacial Surgery Department G Papanikolaou Hospital, Aristotle University, Thessaloniki
Doi: 10.54936/haoms242p08
ABSTRACT:
Objectives: MicroRNAs are a group of endogenous, non-coding, 18–24 nucleotide length single- strand RNAs that regulate gene expression at the post-transcriptional level through mRNA degradation or translational repression. They are involved in regulating diverse cellular biological processes leading to malignancies, including tongue squamous cell carcinoma (SCC). The purpose of this study is to provide the current concepts on the role of specific miRNAs that seem to be important in pathogenesis of tongue SCC.
Material and methods: A narrative literature review was performed on miRNA expression in tongue SCC.
Results: We identified some deregulated miRNAs which seem to have an important role in regulation of cell survival, proliferation, differentiation, migration, invasion, apoptosis and metabolism.
Conclusions: It is therefore important to further explore their roles in carcinogenesis and treatment of tongue SCC.
KEY WORDS: Tongue squamous cell carcinoma; human genome; microRNAs; regulation; target genes; pathways.
Authors:
Chrysostomidis A., Politis S., Koloutsos G., Astreidis I., Paraskevopoulos K., Vahtsevanos K.
Affiliation:
Oral Maxillofacial Surgery Department G Papanikolaou Hospital, Aristotle University, Thessaloniki
Doi: 10.54936/haoms242p08
ABSTRACT:
Objectives: MicroRNAs are a group of endogenous, non-coding, 18–24 nucleotide length single- strand RNAs that regulate gene expression at the post-transcriptional level through mRNA degradation or translational repression. They are involved in regulating diverse cellular biological processes leading to malignancies, including tongue squamous cell carcinoma (SCC). The purpose of this study is to provide the current concepts on the role of specific miRNAs that seem to be important in pathogenesis of tongue SCC.
Material and methods: A narrative literature review was performed on miRNA expression in tongue SCC.
Results: We identified some deregulated miRNAs which seem to have an important role in regulation of cell survival, proliferation, differentiation, migration, invasion, apoptosis and metabolism.
Conclusions: It is therefore important to further explore their roles in carcinogenesis and treatment of tongue SCC.
KEY WORDS: Tongue squamous cell carcinoma; human genome; microRNAs; regulation; target genes; pathways.