Solitary Fibrous Tumor of the Mandible with a malignant component. A Case Report
Stylianos ZANAKIS, Sotirios KYRIAKOU
“Ippokrateio” General Hospital of Athens, Department of Oral and Maxillofacial Surgery (Acting Head: Stylianos Zanakis)
Hellenic Archives of Oral & Maxillofacial Surgery (2018) 1, 3-10
SUMMARY: The solitary fibrous tumor (SFT) is a rare soft tissue tumor that most commonly occurs in the pleural cavity. However, it has also been described in other sites of the body, but only a limited number of SFTs cases have been reported in the oral cavity. Diagnosis depends mainly on microscopic and immunohistochemical features, although imaging may help. Since this tumor shares a number of similar features with other mesenchymal lesions, the histological diagnosis of SFT might be difficult. Awareness of its occurrence in the oral cavity is important in order to avoid confusion with other spindle cell neoplasms. Close follow-up for several years is recommended due to potential late local recurrence. We present, as we believe, the first case of an endosseous SFT, arising in the mandibular bone.
KEY WORDS: Solitary fibrous tumor, Oral cavity, Mandible
REFERENCES
Alawi F, Stratton D, Freedman P: Solitary fibrous tumor of the oral soft tissues: a clinicopathologic and immunohistochemical study of 16 cases. Am J Surg Pathol 25: 900–910, 2001
Al Saanna G, Bovée J, Hornick J, Lazar A: A Review of the WHO Clas- sification of Tumours of Soft Tissue and Bone. WHO, 4th Edition, 2013. http://sarcomahelp.org/reviews/who-classification-sarco-mas.html Date of access: 3/10/2016
Brunnemann RB, Ro JY, Ordonez NG, Mooney J, El-Naggar AG, Ayala AG: Extrapleural solitary fibrous tumor: a clinicopathologic study of 24 cases. Mod Pathol 12: 1034–1042, 1999
England DM, Hochholzer L, McCarthy MJ: Localised benign and ma- lignant fibrous tumors of the pleura: a clinicopathologic review of 223 cases. Am J Surg Pathol 13: 640- 658, 1989
Enzinger FM, Smith BH: Hemangiopericytoma: an analysis of 106 cases. Hum Pathol 7: 61- 82,1976 doi:10.1016/S0046-8177(76)80006-8
Enzinger FM, Weiss SW: Soft Tissue Tumors. In Mosby 3rd Edition: 1995, pp351-380 doi:10.1078/0344-0338-00334
Flint A, Weiss SW: CD-34 and keratin expression distinguishes soli- tary fibrous tumor (fibrous mesothelioma) of the pleura from desmoplastic mesothelioma. Hum Pathol 26: 428- 431,1995. doi:10.1016/0046-8177(95)90145-0
Ganly I, Patel GS, Stambuk EH, Coleman M, Ghossein R, Carlson D,
Edgar M,. Shah PJ: Solitary fibrous tumors of the head and neck: a clinicopathologic and radiologic review. Arch Otolaryngol Head Neck Surg 132(5): 517-525. 2006 doi:10.1001/archotol.132.5.517 Gold JS, Antonescu CR, Hajdu C et al.: Clinicopathologic correlates of solitary fibrous tumors. Cancer 94: 1057-1068, 2002 DOI: 10.1002/cncr.10328
Hanau CA, Miettinen M: Solitary fibrous tumor: histological and im- munohistochemical spectrum of benign and malignant variants presenting at different sites. Hum Pathol 26 : 440–449, 1995 doi:10.1016/0046-8177(95)90147-7
Jordan RCK, Regezi JA: Oral spindle cell neoplasms: a review of 307 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 95(6): 717–724, 2003
Klemperer P, Rabin C: Primary neoplasms of the pleura: a report of five cases. Arch Pathol 11: 385–412, 1931
Langman G: Solitary fibrous tumor: A pathological enigma and clinical dilemma. J Thorac Dis 3(2): 86–87, 2011 DOI: 10.3978/j.issn.
2072-1439.2011.03.04
Perros P, Simpson J, Innes JA, Teale JD, McKnight JA: Non-islet cell tumour-associated hypoglycaemia: In-octreotide imaging and ef- ficacy of octreotide, growth hormone and glucocorticoste- roids. Clin Endocrinol 44: 727- 731, 1996
Sawada N, Ishiwata T, Naito Z, Maeda S, Sugisaki Y, Asano G: Im- munohistochemical localization of endothelial cell markers in soli- tary fibrous tumor. Pathol Int 52: 769–776, 2002
“Ippokrateio” General Hospital of Athens, Department of Oral and Maxillofacial Surgery (Acting Head: Stylianos Zanakis)
Hellenic Archives of Oral & Maxillofacial Surgery (2018) 1, 3-10
SUMMARY: The solitary fibrous tumor (SFT) is a rare soft tissue tumor that most commonly occurs in the pleural cavity. However, it has also been described in other sites of the body, but only a limited number of SFTs cases have been reported in the oral cavity. Diagnosis depends mainly on microscopic and immunohistochemical features, although imaging may help. Since this tumor shares a number of similar features with other mesenchymal lesions, the histological diagnosis of SFT might be difficult. Awareness of its occurrence in the oral cavity is important in order to avoid confusion with other spindle cell neoplasms. Close follow-up for several years is recommended due to potential late local recurrence. We present, as we believe, the first case of an endosseous SFT, arising in the mandibular bone.
KEY WORDS: Solitary fibrous tumor, Oral cavity, Mandible
REFERENCES
Alawi F, Stratton D, Freedman P: Solitary fibrous tumor of the oral soft tissues: a clinicopathologic and immunohistochemical study of 16 cases. Am J Surg Pathol 25: 900–910, 2001
Al Saanna G, Bovée J, Hornick J, Lazar A: A Review of the WHO Clas- sification of Tumours of Soft Tissue and Bone. WHO, 4th Edition, 2013. http://sarcomahelp.org/reviews/who-classification-sarco-mas.html Date of access: 3/10/2016
Brunnemann RB, Ro JY, Ordonez NG, Mooney J, El-Naggar AG, Ayala AG: Extrapleural solitary fibrous tumor: a clinicopathologic study of 24 cases. Mod Pathol 12: 1034–1042, 1999
England DM, Hochholzer L, McCarthy MJ: Localised benign and ma- lignant fibrous tumors of the pleura: a clinicopathologic review of 223 cases. Am J Surg Pathol 13: 640- 658, 1989
Enzinger FM, Smith BH: Hemangiopericytoma: an analysis of 106 cases. Hum Pathol 7: 61- 82,1976 doi:10.1016/S0046-8177(76)80006-8
Enzinger FM, Weiss SW: Soft Tissue Tumors. In Mosby 3rd Edition: 1995, pp351-380 doi:10.1078/0344-0338-00334
Flint A, Weiss SW: CD-34 and keratin expression distinguishes soli- tary fibrous tumor (fibrous mesothelioma) of the pleura from desmoplastic mesothelioma. Hum Pathol 26: 428- 431,1995. doi:10.1016/0046-8177(95)90145-0
Ganly I, Patel GS, Stambuk EH, Coleman M, Ghossein R, Carlson D,
Edgar M,. Shah PJ: Solitary fibrous tumors of the head and neck: a clinicopathologic and radiologic review. Arch Otolaryngol Head Neck Surg 132(5): 517-525. 2006 doi:10.1001/archotol.132.5.517 Gold JS, Antonescu CR, Hajdu C et al.: Clinicopathologic correlates of solitary fibrous tumors. Cancer 94: 1057-1068, 2002 DOI: 10.1002/cncr.10328
Hanau CA, Miettinen M: Solitary fibrous tumor: histological and im- munohistochemical spectrum of benign and malignant variants presenting at different sites. Hum Pathol 26 : 440–449, 1995 doi:10.1016/0046-8177(95)90147-7
Jordan RCK, Regezi JA: Oral spindle cell neoplasms: a review of 307 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 95(6): 717–724, 2003
Klemperer P, Rabin C: Primary neoplasms of the pleura: a report of five cases. Arch Pathol 11: 385–412, 1931
Langman G: Solitary fibrous tumor: A pathological enigma and clinical dilemma. J Thorac Dis 3(2): 86–87, 2011 DOI: 10.3978/j.issn.
2072-1439.2011.03.04
Perros P, Simpson J, Innes JA, Teale JD, McKnight JA: Non-islet cell tumour-associated hypoglycaemia: In-octreotide imaging and ef- ficacy of octreotide, growth hormone and glucocorticoste- roids. Clin Endocrinol 44: 727- 731, 1996
Sawada N, Ishiwata T, Naito Z, Maeda S, Sugisaki Y, Asano G: Im- munohistochemical localization of endothelial cell markers in soli- tary fibrous tumor. Pathol Int 52: 769–776, 2002
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