Ameloblastic fibro-odontoma in a 12 year-old girl. Α case report of a controversial entity
Louiza PAPANTONATOU, Konstantinos I. TOSIOS, Dionysios FOTOPOULOS, Nikolaos NIKITAKIS
Department of Oral Medicine and Pathology, School of Dentistry, National and Kapodistrian University of Athens (Head: Professor N. Nikitakis)
Hellenic Archives of Oral & Maxillofacial Surgery (2019) 3, 103-111
SUMMARY: The clinical, radiographic and histological fea- tures of a mandibular ameloblastic fibro-odontoma (AFO) are presented, and its classification and manage- ment are discussed.
The tumor was an incidental finding in a 12 year-old girl. It manifested as a well-circumscribed radiolucency with radiopaque areas in the ramus and the body of the mandible, surrounding the crown of the impacted second molar and causing jaw perforations. Following enucleation through an intraoral access and extraction of the second permanent molar, complete restoration of the jaw bone was seen in the one year follow-up examination. The microscopic features were consistent with an AFO.
As the neoplastic or hamartomatous nature of AFO and its relation to other mixed odontogenic tumors has not been proved, reports of additional well-documented cases, more comparative studies among AF, AFD, AFO and odontomas, as well as studies of their molecular fea- tures, are needed.
KEY WORDS: odontogenic tumors; ameloblastic fibro-odontoma; odontoma
REFERENCES
Aly N, Amer H, Khatib OE: Ameloblastic fibro-odontoma with chon- droid tissue formation. Contemp Oncol (Pozn) 22: 50-53, 2018 Brown NA, Rolland D, McHugh JB, Weigelin HC, Zhao L, Lim MS, Elenitoba-Johnson KS, Betz BL: Activating FGFR2-RAS-BRAF mu- tations in ameloblastoma. Clin Cancer Res 20: 5517-5526, 2014 Brunner P, Bihl M, Jundt G, Baumhoer D, Hoeller S: BRAFp.V600E mu- tations are not unique to ameloblastoma and are shared by other odontogenic tumors with ameloblastic morphology. Oral Oncol
51: e77-78, 2018
Buchner A, Kaffe I, Vered M: Clinical and radiological profile of ameloblastic fibro-odontoma: an update on an uncommon odon- togenic tumor based on a critical analysis of 114 cases. Head Neck Pathol 7: 54-63, 2013
Chrcanovic BR, Gomez RS: Ameloblastic fibrodentinoma and ameloblastic fibro-odontoma: an updated systematic review of cases reported in the literature. J Oral Maxillofac Surg 75: 1425- 1437, 2017
El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PG: WHO Clas- sification of Head and Neck Tumors. 4th Ed. International Agency for Research on Cancer, Lyon, France; 205 and 222-224, 2017
Galvão CF, Gomes CC, Diniz MG, Vargas PA, de Paula AM, Mosqueda- Taylor A, Loyola AM, Gomez RS: Loss of heterozygosity (LOH) in tumour suppressor genes in benign and malignant mixed odon- togenic tumours. J Oral Pathol Med 41: 389-393, 2012
Gardner DG: The mixed odontogenic tumors. Oral Surg Oral Med Oral Pathol. 58: 166-168, 1984
Ghandehari-Motlagh M, Khosravi Z, Meighani G, Baradaran-Nakhjavani Y: Ameloblastic fibro-odontoma in a 4-year-old boy. Iran J Pediatr 5; 26:e3124, 2016
Kale SG, Shetty A, Balakrishnan J, Purvey P: Ameloblastic fibro-odon- toma with a predominant radiopaque component. Ann Maxillofac Surg 7: 304-307, 2017
Kufta K, Kang S, Alawi SW, Moran A, Panchal N: Ameloblastic fibro- odontoma of the maxilla in a Pierre-Robin sequence patient. Fetal Pediatr Pathol 36: 416-422, 2017
Lucio PSC, Cavalcante RB, Maia RN, Santos ES, Godoy GP: Aggressive ameloblastic fibro-odontoma assessment with CBCT and treat- ment. Eur Arch Paediatr Dent 14: 179-184, 2013
Mashhadiabba F, Shamloo N, Jafari M, Vafadar S: Ameloblastic fibro- odontoma in a 7-month-old infant: A case report. J Dent 18: 234- 236, 2017
Melo Filho MR, Pêgo SPB, Cardoso CM, Rocha BA, Martelli-Júnior H, Flores IL, Dos Santos LAN, Paranaiba LMR: Metachronous ameloblastic fibro-odontoma and dentigerous cyst in the posterior mandible. Gen Dent 65: 69-72, 2017
Nelson NL, Thompson LD: Ameloblastic fibro–odontoma. Head and Neck Pathol 8: 168-170, 2014
Neville BW, Damm DD, Allen CM, Chi AC: Oral and Maxillofacial Pathology. 4th Ed. Elsevier, St. Louis, MO; 671-672, 2016
Park JC, Yang JH, Jo SY, Kim BC, Lee J, Lee W: Giant complex odon- toma in the posterior mandible: A case report and literature re- view. Imaging Sci Dent 48: 289-293, 2018
Philipsen HP, Reichart PA, Praetorius F: Mixed odontogenic tumours and odontomas. Considerations on interrelationship. Review of the literature and presentation of 134 new cases of odontomas. Oral Oncol 33: 86-99, 1997
Reibel J, Grønbaek AB, Poulsen S: Peripheral ameloblastic fibro-odon- toma or peripheral developing complex odontoma: report of a case. Int J Paediatr Dent 21: 468-470, 2011
Ribeiro CM, Santos TT, de Castro SR, de Carli ML, Sperandio FF, Hanemann JA, Pereira AA: Extensive mandibular ameloblastic fibro-odontoma. J Craniofac Surg 27: e563-565, 2016
Scott MP, Bergen MS, Philipone EM, Yoon AJ: Ameloblastic fibro-odon- toma in an adolescent: A case report and review of Literature. J Clin Pediatr Dent 42: 458-460, 2018
Silva AR, Carlos-Bregni R, Vargas PA, de Almeida OP, Lopes MA: Pe- ripheral developing odontoma in newborn. Report of two cases and literature review. Med Oral Pathol Oral Cir Bucal 14: e612- 615, 2019
Singh AK, Kar IB, Mishra N, Sharma P: Ameloblastic fibroodontoma or complex odontoma. Two faces of the same coin. Natl J Maxillofac Surg 7: 92-95, 2016
Siriwardena BSMS, Crane H, Neill N, Abdelkarim R, Brierley DJ, Franklin CD, Farthing PM, Speight PM, Hunter KD: Odontogenic tumors and lesions treated in a single specialist oral and maxillo- facial pathology unit in the United Kingdom in 1992-2016. Oral Surg Oral Med Oral Pathol Oral Radiol 127: 151-166, 2018
Slootweg PJ: An analysis of the interrelationship of the mixed odonto- genic tumors--ameloblastic fibroma, ameloblastic fibro-odontoma, and the odontomas. Oral Surg Oral Med Oral Pathol 51: 266- 276, 1981
Speight PM, Takata T: New tumour entities in the 4th edition of the World Health Organization Classification of Head and Neck tu- mours: odontogenic and maxillofacial bone tumours. Virchows Arch 472: 331-339, 2018
Wright JM, Vered M: Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: Odon- togenic and Maxillofacial Bone Tumors. Head Neck Pathol 11: 68-77, 2017
Zeng XJ, Zhou L, Liao Q, Gong HH: A large ameloblastic fibro- odontoma in the mandible. Quant Imaging Med Surg 2: 135- 136, 2012
Department of Oral Medicine and Pathology, School of Dentistry, National and Kapodistrian University of Athens (Head: Professor N. Nikitakis)
Hellenic Archives of Oral & Maxillofacial Surgery (2019) 3, 103-111
SUMMARY: The clinical, radiographic and histological fea- tures of a mandibular ameloblastic fibro-odontoma (AFO) are presented, and its classification and manage- ment are discussed.
The tumor was an incidental finding in a 12 year-old girl. It manifested as a well-circumscribed radiolucency with radiopaque areas in the ramus and the body of the mandible, surrounding the crown of the impacted second molar and causing jaw perforations. Following enucleation through an intraoral access and extraction of the second permanent molar, complete restoration of the jaw bone was seen in the one year follow-up examination. The microscopic features were consistent with an AFO.
As the neoplastic or hamartomatous nature of AFO and its relation to other mixed odontogenic tumors has not been proved, reports of additional well-documented cases, more comparative studies among AF, AFD, AFO and odontomas, as well as studies of their molecular fea- tures, are needed.
KEY WORDS: odontogenic tumors; ameloblastic fibro-odontoma; odontoma
REFERENCES
Aly N, Amer H, Khatib OE: Ameloblastic fibro-odontoma with chon- droid tissue formation. Contemp Oncol (Pozn) 22: 50-53, 2018 Brown NA, Rolland D, McHugh JB, Weigelin HC, Zhao L, Lim MS, Elenitoba-Johnson KS, Betz BL: Activating FGFR2-RAS-BRAF mu- tations in ameloblastoma. Clin Cancer Res 20: 5517-5526, 2014 Brunner P, Bihl M, Jundt G, Baumhoer D, Hoeller S: BRAFp.V600E mu- tations are not unique to ameloblastoma and are shared by other odontogenic tumors with ameloblastic morphology. Oral Oncol
51: e77-78, 2018
Buchner A, Kaffe I, Vered M: Clinical and radiological profile of ameloblastic fibro-odontoma: an update on an uncommon odon- togenic tumor based on a critical analysis of 114 cases. Head Neck Pathol 7: 54-63, 2013
Chrcanovic BR, Gomez RS: Ameloblastic fibrodentinoma and ameloblastic fibro-odontoma: an updated systematic review of cases reported in the literature. J Oral Maxillofac Surg 75: 1425- 1437, 2017
El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PG: WHO Clas- sification of Head and Neck Tumors. 4th Ed. International Agency for Research on Cancer, Lyon, France; 205 and 222-224, 2017
Galvão CF, Gomes CC, Diniz MG, Vargas PA, de Paula AM, Mosqueda- Taylor A, Loyola AM, Gomez RS: Loss of heterozygosity (LOH) in tumour suppressor genes in benign and malignant mixed odon- togenic tumours. J Oral Pathol Med 41: 389-393, 2012
Gardner DG: The mixed odontogenic tumors. Oral Surg Oral Med Oral Pathol. 58: 166-168, 1984
Ghandehari-Motlagh M, Khosravi Z, Meighani G, Baradaran-Nakhjavani Y: Ameloblastic fibro-odontoma in a 4-year-old boy. Iran J Pediatr 5; 26:e3124, 2016
Kale SG, Shetty A, Balakrishnan J, Purvey P: Ameloblastic fibro-odon- toma with a predominant radiopaque component. Ann Maxillofac Surg 7: 304-307, 2017
Kufta K, Kang S, Alawi SW, Moran A, Panchal N: Ameloblastic fibro- odontoma of the maxilla in a Pierre-Robin sequence patient. Fetal Pediatr Pathol 36: 416-422, 2017
Lucio PSC, Cavalcante RB, Maia RN, Santos ES, Godoy GP: Aggressive ameloblastic fibro-odontoma assessment with CBCT and treat- ment. Eur Arch Paediatr Dent 14: 179-184, 2013
Mashhadiabba F, Shamloo N, Jafari M, Vafadar S: Ameloblastic fibro- odontoma in a 7-month-old infant: A case report. J Dent 18: 234- 236, 2017
Melo Filho MR, Pêgo SPB, Cardoso CM, Rocha BA, Martelli-Júnior H, Flores IL, Dos Santos LAN, Paranaiba LMR: Metachronous ameloblastic fibro-odontoma and dentigerous cyst in the posterior mandible. Gen Dent 65: 69-72, 2017
Nelson NL, Thompson LD: Ameloblastic fibro–odontoma. Head and Neck Pathol 8: 168-170, 2014
Neville BW, Damm DD, Allen CM, Chi AC: Oral and Maxillofacial Pathology. 4th Ed. Elsevier, St. Louis, MO; 671-672, 2016
Park JC, Yang JH, Jo SY, Kim BC, Lee J, Lee W: Giant complex odon- toma in the posterior mandible: A case report and literature re- view. Imaging Sci Dent 48: 289-293, 2018
Philipsen HP, Reichart PA, Praetorius F: Mixed odontogenic tumours and odontomas. Considerations on interrelationship. Review of the literature and presentation of 134 new cases of odontomas. Oral Oncol 33: 86-99, 1997
Reibel J, Grønbaek AB, Poulsen S: Peripheral ameloblastic fibro-odon- toma or peripheral developing complex odontoma: report of a case. Int J Paediatr Dent 21: 468-470, 2011
Ribeiro CM, Santos TT, de Castro SR, de Carli ML, Sperandio FF, Hanemann JA, Pereira AA: Extensive mandibular ameloblastic fibro-odontoma. J Craniofac Surg 27: e563-565, 2016
Scott MP, Bergen MS, Philipone EM, Yoon AJ: Ameloblastic fibro-odon- toma in an adolescent: A case report and review of Literature. J Clin Pediatr Dent 42: 458-460, 2018
Silva AR, Carlos-Bregni R, Vargas PA, de Almeida OP, Lopes MA: Pe- ripheral developing odontoma in newborn. Report of two cases and literature review. Med Oral Pathol Oral Cir Bucal 14: e612- 615, 2019
Singh AK, Kar IB, Mishra N, Sharma P: Ameloblastic fibroodontoma or complex odontoma. Two faces of the same coin. Natl J Maxillofac Surg 7: 92-95, 2016
Siriwardena BSMS, Crane H, Neill N, Abdelkarim R, Brierley DJ, Franklin CD, Farthing PM, Speight PM, Hunter KD: Odontogenic tumors and lesions treated in a single specialist oral and maxillo- facial pathology unit in the United Kingdom in 1992-2016. Oral Surg Oral Med Oral Pathol Oral Radiol 127: 151-166, 2018
Slootweg PJ: An analysis of the interrelationship of the mixed odonto- genic tumors--ameloblastic fibroma, ameloblastic fibro-odontoma, and the odontomas. Oral Surg Oral Med Oral Pathol 51: 266- 276, 1981
Speight PM, Takata T: New tumour entities in the 4th edition of the World Health Organization Classification of Head and Neck tu- mours: odontogenic and maxillofacial bone tumours. Virchows Arch 472: 331-339, 2018
Wright JM, Vered M: Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: Odon- togenic and Maxillofacial Bone Tumors. Head Neck Pathol 11: 68-77, 2017
Zeng XJ, Zhou L, Liao Q, Gong HH: A large ameloblastic fibro- odontoma in the mandible. Quant Imaging Med Surg 2: 135- 136, 2012
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