Ameloblastic Fibroma. A case report and review of the literature
Xristina SOULIOU, Anastasia DELOUSIDOU, Ioulia CHATZISTAMOU, Fotios TZERMPOS
Department of Oral and Maxillofacial Surgery (Head: Professor I. Iatrou) and Laboratory of Basic Sciences (Head: Professor E. Kitraki), Dental School, National and Kapodistrian University of Athens
Hellenic Archives of Oral & Maxillofacial Surgery (2015) 1, 23-29
SUMMARY: Ameloblastic fibroma (AF) has been characterized as a separate clinical entity of odontogenic origin since 1946. The etiology of the lesion remains unknown and a debate arises among scientists as to whether it should be considered as a neoplasm or a hamartoma. AF can be found accidentally during imaging; it usually represents a unilocular or multilocular radiolucency that may or may not be related to unerupted teeth. The ap- pearance in patients aged over 20 years old, the size of more than 5cm of the lesion as well as the scalloped radiographic borders support the notion for the neoplastic nature of the tumor. Surgical excision is the treatment of choice, while an increased recurrence rate has been reported. A case of an ameloblastic fibroma in a 12 years old girl, referred for a painless mandibular swelling, is reported in the present study. Total excision of the lesion was performed and the histological diagnosis was com- patible with AF. There are no signs of recurrence 3 years post-operatively.
KEY WORDS: Ameloblatic fibroma, odontogenic tumor, jaws
REFERENCES
Anesi A, Albanese M, Gerosa R, Corrocher G, Gambarini G, Nocini PF: Mandibular ameloblastic fibroma in 6-years-old girl:a case re- port. Minerva Stomatol, 57:549-555, 2008
Baughman R, Fisher K, Montelone L: Testing your diagnostic skill (#63). Case no. 2. Ameloblastic fibroma, Today’s FDA, 14:24-26, 2002 Buchner A, Vered M: Ameloblastic fibroma: a stage in the development of a hamartomatous odontoma or a true neoplasm? Critical analy-
sis of 162 previously reported cases plus 10 new cases. Oral Surg Oral Med Oral Pathol Oral Radiol 116:598-606, 2013
Büyükakyüz N, Ergun S, Soluk M, Uyumaz N, Tanyeri H: Giant ameloblastic fibroma. Eur J Paediatr Dent, 10:47-50, 2009
Cahn LR, Blum T. Ameloblastic odontoma, case report critically analysed (letter) J Oral Surg, 10: 169–70, 1952
Chen Y, Wang JM, Li TJ: Ameloblastic fibroma: A review of published studies with special reference to its nature and biological behavior. Oral Oncol, 43: 960–9, 2007
Chen Y, Li TJ, Gao Y, Yu SF: Ameloblastic fibroma and related lesions: a clinicopathologic study with reference to their nature and inter- relationship. J Oral Pathol Med, 34:588-595, 2005
Chindia ML, Akama MK, Awange DO: Ameloblastic fibroma at the University of Nairobi Dental Hospital. East Afr Med J, 82:418-421, 2005
Costa DO, Alves AT, Calasans-Maia MD, Cruz RL, Lourenço Sde Q Maxillary ameloblastic fibroma: a case report,Braz Dent J, 22(2): 171-4, 2011
Dimitrakopoulos I, Psomaderis K, Zaramboukas T: Ameloblastic fibroma of the mandible associated with root resorption and unerupted teeth: a case report. Quintessence Int, 39:523-527, 2008
Garcia-Pola Vallejo M, Gonsalez Garcia M, Villalain Alvarez L,Fresno Forcedello M, Lopez-Arranz JS: Ameloblastic fibroma:a case report in a 6 year old. J Clin Pediatr Dent, 25:245-248, 2001
Grecchi F, Zollino I, Lucchese A, Bianco R, Brunelli G,Carinci F: A case of ameloblastic fibroma treated with surgery and orthodontic therapy. Minerva Stomatol, 60:57-63, 2011
Gyulai-Gaál S,Takács D, Szabó G, Suba Z: Mixed odontogenic tumors in children and adolescents. J Craniofac Surg, 18:1338-1342, 2007
Iatrou I, Theologie-Lygidakis N, Tzerbos F, Schoinohoriti OK, Oro-facial tumors and tumor-like lesions in Greek children and adolescents: an 11-year retrospective study. J Craniomaxillofac Surg. Jul; 41(5):437-43. 2013
Isobe K, Morita K, Omura K: Enucleation and repeated dredging treat- ment for a large ameloblastic fibroma in growing young patient: report of a case with difficult treatment planning. Asian J Oral Maxillofac Surg 23:96-98, 2011
Jindal C, Bhola RS: Ameloblastic fibroma in six-year-old male: Hamar- toma or a true neoplasm. J Oral Maxillofac Pathol, 15:303-305, 2011
Kim SG, Jang HS: Ameloblastic fibroma: report of a case. J Oral Max- illofac Surg, 60:216-218, 2002
Kobayashi K, Murakami R, Fujii T, Hirano A: Malignant transformation of ameloblastic fibroma to ameloblastic fibrosarcoma: case report and review of the literature. J Craniomaxillofac Surg, 33:352-355, 2005
Kolomvos N, Chrysomali E, Frangiskos F, Angelopoulos A, Alexandridis C: Ameloblastic fibroma in childhood: A case report. Paidodontia 26(3): 101-105, 2012
Kramer IRH, Pindborg JJ, Shear M.: The WHO histological typing of odontogenic tumours Cancer 70:2988–2994, 1992
Kruse A. Uber die Entwicklung cystischer Geschwu¨lste im Unterkiefer. Arch Path Anat; 124, 137–48, 1891
Kulkarni RS, Sarkar A., Royal S: Recurrent ameloblastic fibroma: report of a rare case.Case Rep Dent, 2013:565721, 2013
Kumar N, Jain S: Aspiration cytology of ameloblastic fibroma:a diag- nostic challenge. Diagn Cytopathol, 29:101-104, 2003
Kousar A1, Hosein MM, Ahmed Z, Minhas K. Rapid sarcomatous trans- formation of an ameloblastic fibroma of the mandible: case report and literature review. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 108(3):e80-5, 2009
Lautner MHW, Eckert AW, Block-Veras R, Seyfert H: Ameloblastic fi- broma of the mandibledreport of a rare benign neoplasm. J Cran- iomaxillofac Surg, 34(suppl 1):183, 2006
Lysell L, Sund G: Αmeloblastic fibroma: report of two cases. Br J Oral Surg. Jul; 16(1):78-85, 1978
Martín-Granizo López R, Ortega L, González Corchón MA,Berguer Sández A: Ameloblastic fibroma of the mandible. Report of two cases. Med Oral, 8:150-153, 2003
McGuinness NJ, Faughnan T, Bennani F, Connolly CE: Ameloblastic fi- broma of the anterior maxilla presenting as a complication of tooth eruption: a case report. J Orthod, 28:115-118, 2001
Mohapatra PK, Choudhury AR, Parkash H: Ameloblastic fibroma in the midline of mandible: a case report. J Clin Pediatr Dent, 24: 321- 327, 2000
Munde A. N, Karle R, 1 and Kale U.B: Ameloblastic fibroma in one- year-old girl,J Oral Maxillofac Pathol 17(1): 149, 2013
Nelson BL, Folk GS: Ameloblastic fibroma. Head Neck Pathol, 3:51- 53, 2009
Pitak-Arnnop P, Chaine A, Dhanuthai K, Bertrand JC, Bertolus C: Ex- tensive ameloblastic fibroma in an adolescent patient: a case re- port with a follow-up of 4 years. Eur J Dent, 3:224-228, 2009
Pereira KD, Bennett KM, Elkins TP, Qu Z: Ameloblastic fibroma of the maxillary sinus. Int J Pediatr Otorhinolaryngol, 68:1473-1477, 2004 Pitak-Arnnop P1, Chaine A, Dhanuthai K, Bertrand JC, Bertolus C: Ex- tensive ameloblastic fibroma in an adolescent patient: a case re-
port with a follow-up of 4 years. Eur J Dent, 3(3): 224-8, 2009 Ravikumar S. Kulkarni, Amitabh Sarkar, Sandeep Goyal, “Recurrent
Ameloblastic Fibroma: Report of a Rare Case,” Case Rep Den, 565721, 2013
Regezi JA, Kerr DA, Courtney RM: Odontogenic tumors: Analysis of 706 cases. J Oral Surg, 36: 771–8, 1978
Reichart, P.A., Philipsen, H.P., Odontogenic Tumors and Allied Lesions Quintessence Publishing, London, 43-59, 2004
Sciubba J, Fantasia J, Kahn L. Development of the teeth and jaws. In: Atlas of tumor pathology: tumors and cysts of the jaws. Wash- ington (DC): Armed Forces Institute of Pathology;pp. 1-5, 2001
Thoma K. H, Goldman H. M, “Odontogenic tumors—a classification based on observations of the epithelial, mesenchymal, and mixed varieties,” The Am J of Path 22: 433–471, 1946.
Trodahl JN. Ameloblastic fibroma. A survey of cases from the Armed Forces Institute of Pathology. Oral Surg Oral Med Oral Pathol, 33: 547–58, 1972
Vasconcelos BC, Andrade ES, Rocha NS, Morais HH, Carvalho RW: Treatment of large ameloblastic fibroma: a case report. J Oral Sci, 51:293-296, 2009
Williams MD, Hanna EY, El-Naggar AK: Anaplastic ameloblastic fi- brosarcoma arising from recurrent ameloblastic fibroma:restricted molecular abnormalities of certain genes to the malignant trans- formation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 104:72-75, 2007
Zallen RD, Preskar MH, McClary SA: Ameloblastic fibroma. J Oral Max- illofac Surg, 40: 513–7, 1983
Department of Oral and Maxillofacial Surgery (Head: Professor I. Iatrou) and Laboratory of Basic Sciences (Head: Professor E. Kitraki), Dental School, National and Kapodistrian University of Athens
Hellenic Archives of Oral & Maxillofacial Surgery (2015) 1, 23-29
SUMMARY: Ameloblastic fibroma (AF) has been characterized as a separate clinical entity of odontogenic origin since 1946. The etiology of the lesion remains unknown and a debate arises among scientists as to whether it should be considered as a neoplasm or a hamartoma. AF can be found accidentally during imaging; it usually represents a unilocular or multilocular radiolucency that may or may not be related to unerupted teeth. The ap- pearance in patients aged over 20 years old, the size of more than 5cm of the lesion as well as the scalloped radiographic borders support the notion for the neoplastic nature of the tumor. Surgical excision is the treatment of choice, while an increased recurrence rate has been reported. A case of an ameloblastic fibroma in a 12 years old girl, referred for a painless mandibular swelling, is reported in the present study. Total excision of the lesion was performed and the histological diagnosis was com- patible with AF. There are no signs of recurrence 3 years post-operatively.
KEY WORDS: Ameloblatic fibroma, odontogenic tumor, jaws
REFERENCES
Anesi A, Albanese M, Gerosa R, Corrocher G, Gambarini G, Nocini PF: Mandibular ameloblastic fibroma in 6-years-old girl:a case re- port. Minerva Stomatol, 57:549-555, 2008
Baughman R, Fisher K, Montelone L: Testing your diagnostic skill (#63). Case no. 2. Ameloblastic fibroma, Today’s FDA, 14:24-26, 2002 Buchner A, Vered M: Ameloblastic fibroma: a stage in the development of a hamartomatous odontoma or a true neoplasm? Critical analy-
sis of 162 previously reported cases plus 10 new cases. Oral Surg Oral Med Oral Pathol Oral Radiol 116:598-606, 2013
Büyükakyüz N, Ergun S, Soluk M, Uyumaz N, Tanyeri H: Giant ameloblastic fibroma. Eur J Paediatr Dent, 10:47-50, 2009
Cahn LR, Blum T. Ameloblastic odontoma, case report critically analysed (letter) J Oral Surg, 10: 169–70, 1952
Chen Y, Wang JM, Li TJ: Ameloblastic fibroma: A review of published studies with special reference to its nature and biological behavior. Oral Oncol, 43: 960–9, 2007
Chen Y, Li TJ, Gao Y, Yu SF: Ameloblastic fibroma and related lesions: a clinicopathologic study with reference to their nature and inter- relationship. J Oral Pathol Med, 34:588-595, 2005
Chindia ML, Akama MK, Awange DO: Ameloblastic fibroma at the University of Nairobi Dental Hospital. East Afr Med J, 82:418-421, 2005
Costa DO, Alves AT, Calasans-Maia MD, Cruz RL, Lourenço Sde Q Maxillary ameloblastic fibroma: a case report,Braz Dent J, 22(2): 171-4, 2011
Dimitrakopoulos I, Psomaderis K, Zaramboukas T: Ameloblastic fibroma of the mandible associated with root resorption and unerupted teeth: a case report. Quintessence Int, 39:523-527, 2008
Garcia-Pola Vallejo M, Gonsalez Garcia M, Villalain Alvarez L,Fresno Forcedello M, Lopez-Arranz JS: Ameloblastic fibroma:a case report in a 6 year old. J Clin Pediatr Dent, 25:245-248, 2001
Grecchi F, Zollino I, Lucchese A, Bianco R, Brunelli G,Carinci F: A case of ameloblastic fibroma treated with surgery and orthodontic therapy. Minerva Stomatol, 60:57-63, 2011
Gyulai-Gaál S,Takács D, Szabó G, Suba Z: Mixed odontogenic tumors in children and adolescents. J Craniofac Surg, 18:1338-1342, 2007
Iatrou I, Theologie-Lygidakis N, Tzerbos F, Schoinohoriti OK, Oro-facial tumors and tumor-like lesions in Greek children and adolescents: an 11-year retrospective study. J Craniomaxillofac Surg. Jul; 41(5):437-43. 2013
Isobe K, Morita K, Omura K: Enucleation and repeated dredging treat- ment for a large ameloblastic fibroma in growing young patient: report of a case with difficult treatment planning. Asian J Oral Maxillofac Surg 23:96-98, 2011
Jindal C, Bhola RS: Ameloblastic fibroma in six-year-old male: Hamar- toma or a true neoplasm. J Oral Maxillofac Pathol, 15:303-305, 2011
Kim SG, Jang HS: Ameloblastic fibroma: report of a case. J Oral Max- illofac Surg, 60:216-218, 2002
Kobayashi K, Murakami R, Fujii T, Hirano A: Malignant transformation of ameloblastic fibroma to ameloblastic fibrosarcoma: case report and review of the literature. J Craniomaxillofac Surg, 33:352-355, 2005
Kolomvos N, Chrysomali E, Frangiskos F, Angelopoulos A, Alexandridis C: Ameloblastic fibroma in childhood: A case report. Paidodontia 26(3): 101-105, 2012
Kramer IRH, Pindborg JJ, Shear M.: The WHO histological typing of odontogenic tumours Cancer 70:2988–2994, 1992
Kruse A. Uber die Entwicklung cystischer Geschwu¨lste im Unterkiefer. Arch Path Anat; 124, 137–48, 1891
Kulkarni RS, Sarkar A., Royal S: Recurrent ameloblastic fibroma: report of a rare case.Case Rep Dent, 2013:565721, 2013
Kumar N, Jain S: Aspiration cytology of ameloblastic fibroma:a diag- nostic challenge. Diagn Cytopathol, 29:101-104, 2003
Kousar A1, Hosein MM, Ahmed Z, Minhas K. Rapid sarcomatous trans- formation of an ameloblastic fibroma of the mandible: case report and literature review. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 108(3):e80-5, 2009
Lautner MHW, Eckert AW, Block-Veras R, Seyfert H: Ameloblastic fi- broma of the mandibledreport of a rare benign neoplasm. J Cran- iomaxillofac Surg, 34(suppl 1):183, 2006
Lysell L, Sund G: Αmeloblastic fibroma: report of two cases. Br J Oral Surg. Jul; 16(1):78-85, 1978
Martín-Granizo López R, Ortega L, González Corchón MA,Berguer Sández A: Ameloblastic fibroma of the mandible. Report of two cases. Med Oral, 8:150-153, 2003
McGuinness NJ, Faughnan T, Bennani F, Connolly CE: Ameloblastic fi- broma of the anterior maxilla presenting as a complication of tooth eruption: a case report. J Orthod, 28:115-118, 2001
Mohapatra PK, Choudhury AR, Parkash H: Ameloblastic fibroma in the midline of mandible: a case report. J Clin Pediatr Dent, 24: 321- 327, 2000
Munde A. N, Karle R, 1 and Kale U.B: Ameloblastic fibroma in one- year-old girl,J Oral Maxillofac Pathol 17(1): 149, 2013
Nelson BL, Folk GS: Ameloblastic fibroma. Head Neck Pathol, 3:51- 53, 2009
Pitak-Arnnop P, Chaine A, Dhanuthai K, Bertrand JC, Bertolus C: Ex- tensive ameloblastic fibroma in an adolescent patient: a case re- port with a follow-up of 4 years. Eur J Dent, 3:224-228, 2009
Pereira KD, Bennett KM, Elkins TP, Qu Z: Ameloblastic fibroma of the maxillary sinus. Int J Pediatr Otorhinolaryngol, 68:1473-1477, 2004 Pitak-Arnnop P1, Chaine A, Dhanuthai K, Bertrand JC, Bertolus C: Ex- tensive ameloblastic fibroma in an adolescent patient: a case re-
port with a follow-up of 4 years. Eur J Dent, 3(3): 224-8, 2009 Ravikumar S. Kulkarni, Amitabh Sarkar, Sandeep Goyal, “Recurrent
Ameloblastic Fibroma: Report of a Rare Case,” Case Rep Den, 565721, 2013
Regezi JA, Kerr DA, Courtney RM: Odontogenic tumors: Analysis of 706 cases. J Oral Surg, 36: 771–8, 1978
Reichart, P.A., Philipsen, H.P., Odontogenic Tumors and Allied Lesions Quintessence Publishing, London, 43-59, 2004
Sciubba J, Fantasia J, Kahn L. Development of the teeth and jaws. In: Atlas of tumor pathology: tumors and cysts of the jaws. Wash- ington (DC): Armed Forces Institute of Pathology;pp. 1-5, 2001
Thoma K. H, Goldman H. M, “Odontogenic tumors—a classification based on observations of the epithelial, mesenchymal, and mixed varieties,” The Am J of Path 22: 433–471, 1946.
Trodahl JN. Ameloblastic fibroma. A survey of cases from the Armed Forces Institute of Pathology. Oral Surg Oral Med Oral Pathol, 33: 547–58, 1972
Vasconcelos BC, Andrade ES, Rocha NS, Morais HH, Carvalho RW: Treatment of large ameloblastic fibroma: a case report. J Oral Sci, 51:293-296, 2009
Williams MD, Hanna EY, El-Naggar AK: Anaplastic ameloblastic fi- brosarcoma arising from recurrent ameloblastic fibroma:restricted molecular abnormalities of certain genes to the malignant trans- formation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 104:72-75, 2007
Zallen RD, Preskar MH, McClary SA: Ameloblastic fibroma. J Oral Max- illofac Surg, 40: 513–7, 1983
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