Chondrosarcoma of the mandible. Case report
George RALLIS, Panagiotis STATHOPOULOS, Constantinos MOUROUZIS, Hussein AL MOMANI, Nicholas ZACHARIADES
Department of Oral & Maxillofacial Clinic, General Hospital of Attica «KAT», Athens, Greece (Head: Ν. Zachariades)
Hellenic Archives of Oral & Maxillofacial Surgery (2010) 2, 105-111
SUMMARY: Chondrosarcoma is a malignant tumour derived from cartilaginous cells. It accounts for 10-12% of all malignant bone tumours and it is the second more common bone tumour after osteosarcoma. However, it rarely occurs in the bones of the visceral cranium. The majority of head and neck chondrosarcomas occur in the upper or lower jaw, with a slightly higher incidence in the upper jaw. Especially, the temporomandibular joint (TMJ) is a rare location. Case report: Α rare case of a large chondrosarcoma of the mandible, developed on an osteochondroma of the mandibular condyle is presented, and the most interesting and unusual pathology results are discussed. A 70-year-old woman presented with a hard painless swelling on the right side of her face, related to the mandibular condyle. A biopsy of the lesion revealed an osteochondroma. The patient refused to undergo the proposed surgical operation, but returned to our hospital after 18 months, with a large tumour mass resulting in facial asymmetry and difficulties in chewing and speaking. The tumour was surgically removed. Micro - scopically, it was a chondrosarcoma, grade II to III. In a certain part, foci of undifferentiated chondrosarcoma were also present. The undifferentiated component displayed histological features of a malignant fibrous histiocytoma developed on a large osteochondroma.
KEY WORDS: Chondrosarcoma, mandible, malignant transformation, osteochondroma
REFERENCES
Ariyoshi Y, Shimahara M: Mesenchymal chondrosarcoma of the maxilla: report of a case. J Oral and Maxillofacial Surgery 57: 733- 737, 1999
Barnes L, Verbin RS, Goodman MA, Peel RL, Appel BN: Disease of the bone and joints, In: Barnes: Surgical pathology of the head and neck. Marcel Dekker Inc. 1985, pp 960-962
Batsakis JG: Tumors of the head and neck. Williams and Wilkins 1979, pp. 383-387
Block DM, Bragoli AJ , Collins DN, Batsakis JG: Mesenchymal chondrosarcomas of the head and neck. J Laryngol Otol 93:405-412, 1979
Burkley BB, Hoffman HT, Baker SR, Thornton AF, McClatchey KD: Chondrosarcoma of the head and neck. Lanrygoscope 100: 1301-1305, 1990
De Vita VT, Hellman S, Rosenberg SA: Cancer principles and practice of oncology. Lippincott 1985, pp. 1325 -1329
Evans Hl, Ayala AG, Romsdahl MM: Prognostic factors in chondrosarcoma of bone. A clinicopathologic analysis with emphasis on histologic grading. Cancer 40: 818-831, 1977
Hackney Fl, Aragon SB, Aufdemorte TB, Holt GR, Van Sickels JE: Chondrosarcoma of the jaws: clinical findings, histopathology and treatment. Oral Surg Oral Med Oral Pathol 71:139-143, 1991
Henderson ED, Dahlin DC: Chondrosarcoma of bone: A study of two hundred and eighty eight cases. J Bone Joint Surg Am 45: 1450-1458, 1963
Iatrou I, Theologi-Lygidakis N, Kypriadis E, Philippidis Th: Chondro - sarcoma of the ethmoid. A case report. Hellenic Archives of Oral and Maxillofacial Surgery 1(2): 96-100, 2000
Molla MR, Ijuhin N, Sugata T, Sakamoto T: Chondrosarcoma of the jaw: report of two cases. J Oral Maxillofac Surg 45:453-457, 1987
Ormiston IW, Piette E, Tideman H, Wu PC: Chondrosarcoma of the mandible presenting as periodontal lesions: report of 2 cases. J Craniomaxillofac Surg 22: 231-235, 1994
Saito K, Unni KK, Wollan PC, Lund BA: Chondrosarcoma of the jaw and facial bones. Cancer 76: 1550-1558, 1995
Sesenna E, Tullio A, Ferrari S: Chondrosarcoma of the temporomandibular joint: a case report and review of the literature. J Oral Maxillofac Surg 55: 1348-1352, 1997
Van Damme Ph. A, de Wilde PCM, Koot RAC, Bruaset I, Slootweg PJ, Ruiter DJ: Juxtacortical chondrosarcoma of the mandible: report of a unique case and review of the literature. Int J Oral Maxillofac Surg 34: 94-98, 2005
Vencio EF, Reeve CM, Unni KK, Nascimento AG: Mesenchymal chondrosarcoma of the jaw bones: clinicopathologic study of 19 cases. Cancer 82: 2350-2355, 1998
Weiss WW Jr, Bennett JA: Chondrosarcoma: a rare tumor of the jaws. J Oral Maxillofac Surg 44:73-79, 1986
Department of Oral & Maxillofacial Clinic, General Hospital of Attica «KAT», Athens, Greece (Head: Ν. Zachariades)
Hellenic Archives of Oral & Maxillofacial Surgery (2010) 2, 105-111
SUMMARY: Chondrosarcoma is a malignant tumour derived from cartilaginous cells. It accounts for 10-12% of all malignant bone tumours and it is the second more common bone tumour after osteosarcoma. However, it rarely occurs in the bones of the visceral cranium. The majority of head and neck chondrosarcomas occur in the upper or lower jaw, with a slightly higher incidence in the upper jaw. Especially, the temporomandibular joint (TMJ) is a rare location. Case report: Α rare case of a large chondrosarcoma of the mandible, developed on an osteochondroma of the mandibular condyle is presented, and the most interesting and unusual pathology results are discussed. A 70-year-old woman presented with a hard painless swelling on the right side of her face, related to the mandibular condyle. A biopsy of the lesion revealed an osteochondroma. The patient refused to undergo the proposed surgical operation, but returned to our hospital after 18 months, with a large tumour mass resulting in facial asymmetry and difficulties in chewing and speaking. The tumour was surgically removed. Micro - scopically, it was a chondrosarcoma, grade II to III. In a certain part, foci of undifferentiated chondrosarcoma were also present. The undifferentiated component displayed histological features of a malignant fibrous histiocytoma developed on a large osteochondroma.
KEY WORDS: Chondrosarcoma, mandible, malignant transformation, osteochondroma
REFERENCES
Ariyoshi Y, Shimahara M: Mesenchymal chondrosarcoma of the maxilla: report of a case. J Oral and Maxillofacial Surgery 57: 733- 737, 1999
Barnes L, Verbin RS, Goodman MA, Peel RL, Appel BN: Disease of the bone and joints, In: Barnes: Surgical pathology of the head and neck. Marcel Dekker Inc. 1985, pp 960-962
Batsakis JG: Tumors of the head and neck. Williams and Wilkins 1979, pp. 383-387
Block DM, Bragoli AJ , Collins DN, Batsakis JG: Mesenchymal chondrosarcomas of the head and neck. J Laryngol Otol 93:405-412, 1979
Burkley BB, Hoffman HT, Baker SR, Thornton AF, McClatchey KD: Chondrosarcoma of the head and neck. Lanrygoscope 100: 1301-1305, 1990
De Vita VT, Hellman S, Rosenberg SA: Cancer principles and practice of oncology. Lippincott 1985, pp. 1325 -1329
Evans Hl, Ayala AG, Romsdahl MM: Prognostic factors in chondrosarcoma of bone. A clinicopathologic analysis with emphasis on histologic grading. Cancer 40: 818-831, 1977
Hackney Fl, Aragon SB, Aufdemorte TB, Holt GR, Van Sickels JE: Chondrosarcoma of the jaws: clinical findings, histopathology and treatment. Oral Surg Oral Med Oral Pathol 71:139-143, 1991
Henderson ED, Dahlin DC: Chondrosarcoma of bone: A study of two hundred and eighty eight cases. J Bone Joint Surg Am 45: 1450-1458, 1963
Iatrou I, Theologi-Lygidakis N, Kypriadis E, Philippidis Th: Chondro - sarcoma of the ethmoid. A case report. Hellenic Archives of Oral and Maxillofacial Surgery 1(2): 96-100, 2000
Molla MR, Ijuhin N, Sugata T, Sakamoto T: Chondrosarcoma of the jaw: report of two cases. J Oral Maxillofac Surg 45:453-457, 1987
Ormiston IW, Piette E, Tideman H, Wu PC: Chondrosarcoma of the mandible presenting as periodontal lesions: report of 2 cases. J Craniomaxillofac Surg 22: 231-235, 1994
Saito K, Unni KK, Wollan PC, Lund BA: Chondrosarcoma of the jaw and facial bones. Cancer 76: 1550-1558, 1995
Sesenna E, Tullio A, Ferrari S: Chondrosarcoma of the temporomandibular joint: a case report and review of the literature. J Oral Maxillofac Surg 55: 1348-1352, 1997
Van Damme Ph. A, de Wilde PCM, Koot RAC, Bruaset I, Slootweg PJ, Ruiter DJ: Juxtacortical chondrosarcoma of the mandible: report of a unique case and review of the literature. Int J Oral Maxillofac Surg 34: 94-98, 2005
Vencio EF, Reeve CM, Unni KK, Nascimento AG: Mesenchymal chondrosarcoma of the jaw bones: clinicopathologic study of 19 cases. Cancer 82: 2350-2355, 1998
Weiss WW Jr, Bennett JA: Chondrosarcoma: a rare tumor of the jaws. J Oral Maxillofac Surg 44:73-79, 1986
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