Small cell carcinoma of the submandibular salivary gland. Case report
George RALLIS, Panagiotis STATHOPOULOS, Orestis TSELKAS, Alexandra SKLAVOUNOU, Nicolaos ZACHARIADES
Oral & Maxillofacial Clinic, General Hospital of Attica «KAT» (Head: N. Zachariades)
Hellenic Archives of Oral & Maxillofacial Surgery (2010) 1, 33-37
SUMMARY: Small cell carcinoma is a malignant tumor usually developing in the lungs where it accounts for 20% to 25% of carcinomas. Pulmonary small cell carcinoma is an aggressive malignant tumor, which can lead to death within a short period of time, if left untreated, while 85% of the cases involve smokers. Small cell carcinoma can also occur in extrapulmonary sites with most common site in the head and neck region being the larynx. Primary lesions of small cell carcinoma in the submandibular salivary gland are extremely rare. The early diagnosis and treatment of such a lesion can to lead to the patient’s successful recovery. The aim of this article was to present a rare case of a small cell carcinoma of the submandibular gland. Α 79-year-old female patient, who presented with a mild painful swelling of the left mandibular region. After the detailed laboratory examinations and the surgical debridement of the left submandibular triangle that were conducted, the histopathological examination revealed a small cell carcinoma of the concomitant submandibular salivary gland. Five years post-operatively, the patient is free of disease.
KEY WORDS: Small cell carcinoma, lungs, submandibular salivary gland
REFERENCES
Donoff RB, Albert T, Olson DJ, Guralnick W: Metastatic bronchoge - nic carcinoma to the mandible. J Oral Surg 34: 1007-1011,1976
Gnepp DR, Corio RL, Brannon RB: Small cell carcinoma of the major salivary glands. Cancer. 58(3):705-714,1986 Johnson DH: Management of small cell lung cancer: Current state of the art. Chest 116 : 525-530,1998
Kim SWG, Jang HS: Small cell carcinoma of the oral cavity: Report of a case. J Oral Maxillofac Surg 59: 680-684,2001
Langdon JD: Saliivary gland surgery. In operative maxillofacial surgery. Editors: Langdon JD, Patel MF. London Chapman & Hall, pp.375- 380, 1998
Lin YC, Wu HP, Tzeng JE: Small-cell undifferentiated carcinoma of the submandibular gland: an extremely rare extrapulmonary site .Am J Otolaryngol. 26(1):60-63,2005
Rodriguez JC, Fresno MF, Junquera LM, Hernandez G, Lopez JS: Small cell undifferentiated carcinoma of the submandibular gland with neuroendocrine features. Ann. Otol. Rhinol. Laryngol. 113(1):55-59,2004
Rosell MR, Lluansi J, Fernandez M, Sanchez JM, Adrados M: Neuro - endocrine tumor of the submaxillary gland. Apropos of a case. Acta Otorrinolaringol Esp.42(2):144-146,1991
Shah JP: Salivary glands. In Head and Neck Surgery. Second Edition Mosby: 431-460, 1996.
Svirsky JA, Dent CD, Mandalinich D: Rapidly enlarging gingival mass. JADA 119: 657-659,1989
Toyosawa S, Ohnishi A, Ito R, Ogawa Y, Kishino M, Yasui Y, Kitamura R, Matsuya T, Ishida T, Ijuhin N: Small cell undifferentiated carcinoma of the submandibular gland: immunohistochemical evidence of myoepithelial, basal and luminal cell features Pathol Int. 49(10):887-892,1999
Walters DM, Little SC, Hessler RB, Gourin CG: Small cell carcinoma of the submandibular gland: a rare small round blue cell tumor Am J Otolaryngol. 28(2):118-121,2007
Zachariades N, Rallis G, Mezitis M, Komis C, Machera H: Large cervical mass in an 8-month-old infant. J Oral Maxillofac Surg 60: 1472-1478 ,2002
Zachariades N, Koumoura F, Sklavounou – Andrikopoulou A, Papadakis D: Small cell carcinoma metastatic to the mandible. Report of a case. Int J Oral Maxillofac Surg 33:307-309,2004
Oral & Maxillofacial Clinic, General Hospital of Attica «KAT» (Head: N. Zachariades)
Hellenic Archives of Oral & Maxillofacial Surgery (2010) 1, 33-37
SUMMARY: Small cell carcinoma is a malignant tumor usually developing in the lungs where it accounts for 20% to 25% of carcinomas. Pulmonary small cell carcinoma is an aggressive malignant tumor, which can lead to death within a short period of time, if left untreated, while 85% of the cases involve smokers. Small cell carcinoma can also occur in extrapulmonary sites with most common site in the head and neck region being the larynx. Primary lesions of small cell carcinoma in the submandibular salivary gland are extremely rare. The early diagnosis and treatment of such a lesion can to lead to the patient’s successful recovery. The aim of this article was to present a rare case of a small cell carcinoma of the submandibular gland. Α 79-year-old female patient, who presented with a mild painful swelling of the left mandibular region. After the detailed laboratory examinations and the surgical debridement of the left submandibular triangle that were conducted, the histopathological examination revealed a small cell carcinoma of the concomitant submandibular salivary gland. Five years post-operatively, the patient is free of disease.
KEY WORDS: Small cell carcinoma, lungs, submandibular salivary gland
REFERENCES
Donoff RB, Albert T, Olson DJ, Guralnick W: Metastatic bronchoge - nic carcinoma to the mandible. J Oral Surg 34: 1007-1011,1976
Gnepp DR, Corio RL, Brannon RB: Small cell carcinoma of the major salivary glands. Cancer. 58(3):705-714,1986 Johnson DH: Management of small cell lung cancer: Current state of the art. Chest 116 : 525-530,1998
Kim SWG, Jang HS: Small cell carcinoma of the oral cavity: Report of a case. J Oral Maxillofac Surg 59: 680-684,2001
Langdon JD: Saliivary gland surgery. In operative maxillofacial surgery. Editors: Langdon JD, Patel MF. London Chapman & Hall, pp.375- 380, 1998
Lin YC, Wu HP, Tzeng JE: Small-cell undifferentiated carcinoma of the submandibular gland: an extremely rare extrapulmonary site .Am J Otolaryngol. 26(1):60-63,2005
Rodriguez JC, Fresno MF, Junquera LM, Hernandez G, Lopez JS: Small cell undifferentiated carcinoma of the submandibular gland with neuroendocrine features. Ann. Otol. Rhinol. Laryngol. 113(1):55-59,2004
Rosell MR, Lluansi J, Fernandez M, Sanchez JM, Adrados M: Neuro - endocrine tumor of the submaxillary gland. Apropos of a case. Acta Otorrinolaringol Esp.42(2):144-146,1991
Shah JP: Salivary glands. In Head and Neck Surgery. Second Edition Mosby: 431-460, 1996.
Svirsky JA, Dent CD, Mandalinich D: Rapidly enlarging gingival mass. JADA 119: 657-659,1989
Toyosawa S, Ohnishi A, Ito R, Ogawa Y, Kishino M, Yasui Y, Kitamura R, Matsuya T, Ishida T, Ijuhin N: Small cell undifferentiated carcinoma of the submandibular gland: immunohistochemical evidence of myoepithelial, basal and luminal cell features Pathol Int. 49(10):887-892,1999
Walters DM, Little SC, Hessler RB, Gourin CG: Small cell carcinoma of the submandibular gland: a rare small round blue cell tumor Am J Otolaryngol. 28(2):118-121,2007
Zachariades N, Rallis G, Mezitis M, Komis C, Machera H: Large cervical mass in an 8-month-old infant. J Oral Maxillofac Surg 60: 1472-1478 ,2002
Zachariades N, Koumoura F, Sklavounou – Andrikopoulou A, Papadakis D: Small cell carcinoma metastatic to the mandible. Report of a case. Int J Oral Maxillofac Surg 33:307-309,2004
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