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    • Volume 23 >
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        • HAOMS (2022) 3, Editorial
        • HAOMS (2022) 3, 159-169
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        • Proceeding of the HAOMS 2022 Conference >
          • CONFLICT OF COVID-19 PANDEMIC RESTRICTIONS IN THE FIRST DIAGNOSES OF SKIN CANCER IN 2020: A SINGLE-CENTRE STUDY
          • MARSUPIALIZATION OF LARGE MANBILULAR RESIDUAL CYSTS. TWO CASE REPORTS.
          • PERI-IMPLANTITIS IN DENTAL IMPLANTS PLACED IN AUGMENTED BONE: A CASE REPORT.
          • SUBSEQUENT THERAPEUTIC TREATMENT OF MEMBRANE EXPOSURE AFTER GBR IN THE ANTERIOR MAXILLAE: A CASE REPORT
          • Estimation of recurrence rates with off-label use of 5% imiquimod as an adjuvant therapy after surgery or as a monotherapy in patients with lentigo maligna.
          • The effect of orthodontic treatment on the periodontal tissues
          • Root coverage techniques for gum recession
          • “THUNDER – LIKE” PLASTY FOR TWIN NASAL TIP DEFECTS. TECHNIQUE DESCRIPTION AND INDICATIONS
          • GUIDED IMPLANT PLACEMENT ON EDENTULOUS MAXILLA TO AVOID DAMAGE TO ACCESSORY BRANCHES OF THE CANALIS SINUOSUS: A CASE REPORT
          • BΟΝΕ REGENERATION IN HEALTHY AND OSTEOPOROTIC CONDITIONS. PRECLINICAL EVIDENCE.
          • EVALUATING THE MINIMAL CLINICALLY IMPORTANT DIFFERENCES IN QUALITY-OF-LIFE QUESTIONNAIRES EORTC QLQ-C30 AND QLQ-HN35, IN HEAD AND NECK CANCER PATIENTS ACCORDING TO THE EUROPEAN ORGANIZATION FOR RESEARCH AND TREATMENT OF CANCER.
          • AUTOLOGOUS BONE GRAFTS – INDICATIONS AND RESTRICTIONS
          • VERTICAL RIDGE AUGMENTATION IN THE POSTERIOR MANDIBLE – A CASE REPORT
          • RARE PRESENCE OF FOREIGN BODIES IN MAXILLARY SINUSES DUE TO DENTAL PROCEDURES; A RETROSPECTIVE CASE SERIES ANALYSIS OF TREATMENT.
          • A MAXILLARY LESION WITH A RARE DIAGNOSIS; A CASE REPORT OF EWING SARCOMA
          • MULTIPLE CERVICAL SPACES’ SECONDARY EMPHYSEMA CAUSED BY A MANDIBULAR ANGLE FRACTURE FROM ASSAULT, REPORT OF A CASE.
          • HEAD AND NECK RECONSTRUCTION WITH FREE VASCULARIZED FLAPS; OUR EXPERIENCE
          • REMODELLING OF THE SUPERFICIAL VASCULAR NETWORK OF SKIN FLAPS IN RATS, FOLLOWING A VASODILATORY CREAM APPLICATION
          • HEAD AND NECK RECONSTRUCTION WITH MAJOR REGIONAL FLAPS; WHAT THE COVID-19 PANDEMIC TAUGHT US
          • SURGICAL TREATMENT OF MEDICATION RELATED OSTEONECROSIS OF THE JAW USING PRF
          • INTRAORAL LIPOMAS: REVIEW OF LITERATURE AND REPORT OF CLINICAL CASES
          • ALVEOLAR RIDGE PRESERVATION IN THE AESTHETIC ZONE.
          • SURGICAL TREATMENT OF TEMPOROMANDIBULAR JOINT ANKYLOSIS WITH COSTO- CHONDRAL GRAFT APPLICATION: CASE PRESENTATION
          • EAGLE SYNDROME: ETIOLOGY, DIAGNOSIS AND TREATMENT. A LITERATURE REVIEW AND PRESENTATION OF CASES
          • HORIZONTAL AND VERTICAL RIDGE AUGMENTATION AND ITS TECHNIQUES
          • HAS THE COVID-19 PANDEMIC INFLUENCED THE MANAGEMENT OF HEAD AND NECK CANCER PATIENTS? A SINGLE-CENTRE STUDY
          • PIEZOELECTRIC SURGERY VERSUS CONVENTIONAL ROTATORY BURS FOR SINUS LIFT SURGERY: A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS.
          • THYROGLOSSAL DUCT CYSTS, A CASE SERIES IN ORAL MAXILLOFACIAL SURGERY DEPARTMENT OF G. PAPANIKOLAOU HOSPITAL OF THESSALONIKI.
          • LARGE PERIOCULAR DEFECTS RECONSTRUCTION WITH AXIAL AND RANDOM PATTERN FLAPS. INDICATIONS, TECHNIQUE DESCRIPTION AND FOLLOW-UP ON OCCASION OF 4 CASES
          • SUCCESSFUL PERIOPERATIVE MANAGEMENT OF HIGH-RISK ELDERLY PATIENTS WITH ADVANCED HEAD & NECK CANCER IN THE COVID ERA. OUR EXPERIENCE.
          • HAS THE COVID-19 PANDEMIC INFLUENCED THE NUMBER OF PATIENTS WITH CERVICOFACIAL INFECTIONS? A SINGLE CENTRE STUDY
          • HAS THE COVID-19 PANDEMIC AFFECTED THE PREVALENCE OF MAXILLOFACIAL FRACTURES? A SINGLE CENTRE STUDY
          • CERVICAL VAGUS NERVE SCHWANNOMA IN AN ADULT PATIENT: A CASE REPORT
          • PTERYGOID PLATE IMPLANTS FOR THE REHABILITATION OF THE ATROPHIC POSTERIOR MAXILLA: SURGICAL TECHNIQUE AND REPORT OF CASES.
          • HYBRID VERRUCUS CARCINOMA OF THE ORAL CAVITY: A CASE REPORT AND REVIEW OF THE LITERATURE
          • A COMPARISON OF GBR MEMBRANES
          • A RARE CASE OF CERVICAL CYSTIC LYMPHANGIOMA IN AN ADULT PATIENT
          • ΟSSEODENSIFICATION. A PROMISING NEW TECHNIQUE.
          • PERFORATION OF SINUS MEMBRANE DURING SINUS FLOOR ELEVATION: REPAIR WITH COLLAGEN MEMBRANE AND METHOD RELIABILITY
          • “LIP SHAVE” TECHNIQUE: LITERATURE REVIEW AND CASE PRESENTATION
          • IMPLANT PLACEMENT WITH SIMULTANEOUS SINUS FLOOR ELEVATION IN THE PRESENCE OF A LARGE SINUS MUCOCELE: A CASE REPORT
          • Foundation of the posterior occlusal support of the osseointergrated prostheses on the remaining residual ridge.
          • Dental implants surgery and systematic diseases
          • Nasal reconstruction after skin cancer surgery; presentation of treatment modalities for medically compromised patients.
          • “STICKY TOOTH”. SOCKET PRESERVATION BY USING AN AUTOLOGOUS DENTINE GRAFT IN COMBINATION WITH PLASMA RICH FIBRIN. CASE REPORT AND A TWO YEARS FOLLOW UP.
          • Immunomodulatory effects of Nd:YAG (1064 nm) and diode laser (810 nm) wavelengths to LPS-challenged human gingival fibroblasts
          • Is aseptic bone necrosis a cause for early implant failure in patients with metal allergies? – A case report and literature review
          • CLINICAL APPLICATIONS OF SAFESCRAPER® IN MAXILLARY SINUS FLOOR ELEVATION AND RIDGE AUGMENTATION
          • A novel crestal protocol for the application of denatured Albumin in minimally invasive Implantology and Sinus Piezosurgery - Preliminary Results of a Pilot Study
          • Lateral cephalometric changes and stability of BSSO versus IVRO for mandibular setback surgery: A systematic review and meta-analysis.
          • BONE REGENERATION FOR DENTAL IMPLANT PLACEMENT: A 5-YEAR RETROSPECTIVE STUDY OF 358 CASES
    • Volume 22 >
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        • HAOMS (2021) 1, 5-11
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        • Editorial 2, 2021
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        • Editorial 3, 2021
        • HAOMS (2021) 3, 141-154
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        • HAOMS (2019) 3, 103-111
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    • Volume 15 >
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        • HAOMS (2014) 1, 1-10
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Medication related osteonecrosis of the jaws. Literature review

Medication related osteonecrosis of the jaws. Literature review

Paris TAMIOLAKIS, Griogorios THERMOS, Anastasios CHAROULIS, Εvanthia CHRYSOMALI, Alexandra SKLAVOUNOU-ANDRIKOPOULOU
 
Department of Oral Medicine and Pathology, School of Dentistry, National and Kapodistrian University of Athens, Greece (Head: Professor A. Sklavounou-Andrikopoulou)

​Hellenic Archives of Oral & Maxillofacial Surgery (2018) 1, 11-34

SUMMARY: Medication related osteonecrosis of the jaws (MRONJ) is a clinical entity that may develop in patients receiving antiresorprtive (bisphosphonates and deno- sumab) or antiangiogenic agents. The main objective of this article is to review the pertinent literature regarding medications that may cause MRONJ, its pathophysiology, etiologic factors, epidemiological, radiological and clini- copathological features as well as therapeutic approaches. It is critical for the dentist, to inform the patients at risk for developing MRONJ, to be able to timely diagnose the disease in order to contribute to its prevention and proper management. Diagnosis is based on the patient’s medical history and clinical findings. Medical history should be thoroughly investigated with emphasis on medications related to MRONJ. Maintenance of an ex- cellent oral hygiene and intensive dental care before and during treatment, are preventive measures aiming to re- duce the risk of MRONJ. Treatment protocol is related to the stage of the disease and ranges from conservative management (topical antimicrobial agents in combination with systemic antibiotics), to surgical interventions per- formed by specialized surgeons. Histopathological exam- ination of the surgically removed specimens is mandatory in order to exclude other pathological conditions or metastatic disease.
KEY WORDS: Osteonecrosis of the jaws, Medication re- lated Osteonecrosis of the jaws

REFERENCES

AAOM Clinical Practice Statement Subject: The use of serum C-ter- minal telopeptide cross-link of type 1 collagen (CTX) testing in predicting risk of osteonecrosis of the jaw (ONJ). Oral Surg Oral Med Oral Pathol Oral Radiol 124:367-368, 2017
Aghaloo TL, Cheong S, Bezouglaia O, Kostenuik P, Atti E, Dry SM, Pirih FQ, Tetradis S. RANKL inhibitors induce osteonecrosis of the jaw in mice with periapical disease. J Bone Miner Res 29:843- 54, 2014
Aghaloo TL, Hazboun R, Tetradis S. Pathophysiology of Osteonecro- sis of the Jaws. Oral Maxillofac Surg Clin North Am 27:489-96, 2015
Aghaloo TL, Kang B, Sung EC, Shoff M, Ronconi M, Gotcher JE, Be- zouglaia O, Dry SM, Tetradis S. Periodontal disease and bispho- sphonates induce osteonecrosis of the jaws in the rat. J Bone Miner Res 26:1871-82, 2011
Aghaloo TL, Tetradis S. Osteonecrosis of the Jaw in the Absence of Antiresorptive or Antiangiogenic Exposure: A Series of 6 Cases. J Oral Maxillofac Surg 75:129-142, 2017
Allen MR. Medication-Related Osteonecrosis of the Jaw: Basic and Translational Science Updates. Oral Maxillofac Surg Clin North Am 27:497-508, 2015
Anavi-Lev K, Anavi Y, Chaushu G, Alon DM, Gal G, Kaplan I. Bispho- sphonate related osteonecrosis of the jaws: clinico-pathological investigation and histomorphometric analysis. Oral Surg Oral Med Oral Pathol Oral Radiol 115:660-6, 2013
Arduino PG, Scully C, Chiusa L, Broccoletti R. Oral squamous cell carcinoma arising in a patient after hematopoietic stem cell transplantation with bisphosphonate-related osteonecrosis of the jaws. Case Rep Dent 2015:831418.
Bagan J, Peydró A, Calvo J, Leopoldo M, Jiménez Y, Bagan L. Medica- tion-related osteonecrosis of the jaw associated with bisphos- phonates and denosumab in osteoporosis. Oral Dis 22: 324-9, 2016
Bagan JV, Cibrian RM, Lopez J, Leopoldo-Rodado M, Carbonell E, Bagán L, Utrilla J, Scully C. Sclerosis in bisphosphonate-related os- teonecrosis of the jaws and its correlation with the clinical stages: study of 43 cases. Br J Oral Maxillofac Surg 53: 257-62, 2015
Bedogni A, Fedele S, Bedogni G, Scoletta M, Favia G, Colella G, Agrillo A, Bettini G et al. Staging of osteonecrosis of the jaw re- quires computed tomography for accurate definition of the ex- tent of bony disease. Br J Oral Maxillofac Surg 52: 603-8, 2014 Beth-Tasdogan NH, Mayer B, Hussein H, Zolk O. Interventions for managing medication-related osteonecrosis of the jaw.
Cochrane Database Syst Rev 10:CD012432, 2017
Bodem JP, Kargus S, Engel M, Hoffmann J, Freudlsperger C. Value of nonsurgical therapeutic management of stage I bisphosphonate- related osteonecrosis of the jaw. J Craniomaxillofac Surg 43:1139-43, 2015
Bodem JP, Schaal C, Kargus S, Saure D, Mertens C, Engel M, Hoff- mann J, Freudlsperger C. Surgical management of bisphospho- nate-related osteonecrosis of the jaw stages II and III. Oral Surg Oral Med Oral Pathol Oral Radiol 121: 367-72, 2016
Boff RC, Salum FG, Figueiredo MA, Cherubini K. Important aspects regarding the role of microorganisms in bisphosphonate-related osteonecrosis of the jaws. Arch Oral Biol 59:790-9, 2014
Carlson ER, Fleisher KE, Ruggiero SL. Metastatic cancer identified in osteonecrosis specimens of the jaws in patients receiving intra- venous bisphosphonate medications. J Oral Maxillofac Surg 71:2077-86, 2013
Cheong S, Sun S, Kang B, Bezouglaia O, Elashoff D, McKenna CE, Aghaloo TL, Tetradis S. Bisphosphonate uptake in areas of tooth extraction or periapical disease. J Oral Maxillofac Surg 72:2461- 8, 2014
Chiandussi S, Biasotto M, Dore F, Cavalli F, Cova MA, Di Lenarda
R. Clinical and diagnostic imaging of bisphosphonate-associated osteonecrosis of the jaws. Dentomaxillofac Radiol 35:236-43, 2006
Cosman F, Crittenden DB, Adachi JD, Binkley N, Czerwinski E, Ferrari S, Hofbauer LC, Lau E, Lewiecki EM, Miyauchi A, Zerbini CA, Milmont CE, Chen L, Maddox J, Meisner PD, Libanati C, Grauer
A. Romosozumab Treatment in Postmenopausal Women with Osteoporosis. N Engl J Med 375:1532-1543, 2016
Dal Prá KJ, Lemos CA, Okamoto R, Soubhia AM, Pellizzer EP. Efficacy of the C-terminal telopeptide test in predicting the development of bisphosphonate-related osteonecrosis of the jaw: a systematic review. Int J Oral Maxillofac Surg 46:151-156, 2017
de Molon RS, Hsu C, Bezouglaia O, Dry SM, Pirih FQ, Soundia A, Cunha  FQ,  Cirelli  JA,  Aghaloo  TL,  Tetradis  S.  Rheumatoid Arthritis Exacerbates the Severity of Osteonecrosis of the Jaws (ONJ) in Mice. A Randomized, Prospective, Controlled Animal Study. J Bone Miner Res 31:1596-607, 2016
de Molon RS, Shimamoto H, Bezouglaia O, Pirih FQ, Dry SM, Kostenuik P, Boyce RW, Dwyer D, Aghaloo TL, Tetradis S. OPG-Fc but Not Zoledronic Acid Discontinuation Reverses Os- teonecrosis  of  the  Jaws  (ONJ)  in  Mice.  J  Bone  Miner  Res 30:1627-40, 2015
de-Freitas NR, Lima LB, de-Moura MB, Veloso-Guedes CC, Simamoto-Júnior PC, de-Magalhães D. Bisphosphonate treat- ment and dental implants: A systematic review. Med Oral Patol Oral Cir Bucal 21:e644-51, 2016
DeSesa CR, Appugounder S, Haberland C, Johnson MP. Osteonecro- sis of the Jaw in Association With Chemotherapy in the Setting of Cutaneous T-Cell Lymphoma. J Oral Maxillofac Surg 74:292- 301, 2016
Di Fede O, Bedogni A, Giancola F, Saia G, Bettini G, Toia F, D'A- lessandro N, Firenze A, Matranga D, Fedele S, Campisi G. BRONJ in patients with rheumatoid arthritis: a multicenter case series. Oral Dis 22:543-8, 2016
Dimopoulos MA, Kastritis E, Bamia C, Melakopoulos I, Gika D, Rous- sou M, Migkou M, Eleftherakis-Papaiakovou E, Christoulas D, Terpos E, Bamias A. Reduction of osteonecrosis of the jaw (ONJ) after implementation of preventive measures in patients with multiple myeloma treated with zoledronic acid. Ann Oncol 20:117-20, 2009
Dodson TB. The Frequency of Medication-related Osteonecrosis of the Jaw and its Associated Risk Factors. Oral Maxillofac Surg Clin North Am 27:509-16, 2015
Donetti E, Gualerzi A, Sardella A, Lodi G, Carrassi A, Sforza C. Al- endronate impairs epithelial adhesion, differentiation and prolif- eration in human oral mucosa. Oral Dis 20:466-72, 2014
Fantasia JE. Bisphosphonates--what the dentist needs to know: prac- tical considerations. J Oral Maxillofac Surg 67:53-60, 2009
Fantasia JE. The Role of Antiangiogenic Therapy in the Development of Osteonecrosis of the Jaw. Oral Maxillofac Surg Clin North Am 27:547-53, 2015
Fedele S, Bedogni G, Scoletta M, Favia G, Colella G, Agrillo A, Bettini G, Di Fede O, Oteri G, Fusco V, Gabriele M, Ottolenghi L, Valsecchi S, Porter S, Fung PP, Saia G, Campisi G, Bedogni A. Up to a quarter of patients with osteonecrosis of the jaw asso- ciated with antiresorptive agents remain undiagnosed. Br J Oral Maxillofac Surg 53:13-7, 2015
Fliefel R, Tröltzsch M, Kühnisch J, Ehrenfeld M, Otto S. Treatment strategies and outcomes of bisphosphonate-related osteonecro- sis of the jaw (BRONJ) with characterization of patients: a sys- tematic review. Int J Oral Maxillofac Surg 44:568-85, 2015
Fung P, Bedogni G, Bedogni A, Petrie A, Porter S, Campisi G, Bagan J, Fusco V, Saia G, Acham S, Musto P, Petrucci MT, Diz P, Colella G, Mignogna MD, Pentenero M, Arduino P, Lodi G, Maiorana C, Manfredi M, Hallberg P, Wadelius M, Takaoka K, Leung YY, Bonacina R, Schiødt M, Lakatos P, Taylor T, De Riu G, Favini G, Rogers SN, Pirmohamed M, Nicoletti P; GENVABO Consor- tium, Fedele S. Time to onset of bisphosphonate-related os- teonecrosis of the jaws: a multicentre retrospective cohort study. Oral Dis 23:477-483, 2017
Fung PL, Nicoletti P, Shen Y, Porter S, Fedele S. Pharmacogenetics of Bisphosphonate-associated Osteonecrosis of the Jaw. Oral Maxillofac Surg Clin North Am 27:537-46, 2015
Gabbert TI, Hoffmeister B, Felsenberg D. Risk factors influencing the duration of treatment with bisphosphonates until occurrence of an osteonecrosis of the jaw in 963 cancer patients. J Cancer Res Clin Oncol 141:749-58, 2015
Gander T, Obwegeser JA, Zemann W, Grätz KW, Jacobsen C. Ma- lignancy mimicking bisphosphonate-associated osteonecrosis of the jaw: a case series and literature review. Oral Surg Oral Med Oral Pathol Oral Radiol 117:32-6, 2014
Gaudin E, Seidel L, Bacevic M, Rompen E, Lambert F. Occurrence and risk indicators of medication-related osteonecrosis of the jaw after dental extraction: a systematic review and meta-analy- sis. J Clin Periodontol 42:922-32, 2015
Goodday RH. Preventive Strategies for Patients at Risk of Medica- tion-related Osteonecrosis of the Jaw. Oral Maxillofac Surg Clin North Am 27:527-36, 2015
Goodwin JS, Zhou J, Kuo YF, Baillargeon J. Risk of Jaw Osteonecrosis After Intravenous Bisphosphonates in Cancer Patients and Pa- tients Without Cancer. Mayo Clin Proc 92:106-113, 2017
Hallmer F, Bjørnland T, Andersson G, Becktor JP, Kristoffersen AK, Enersen M. Bacterial diversity in medication-related osteonecro- sis of the jaw. Oral Surg Oral Med Oral Pathol Oral Radiol 123:436-444, 2017
Hallmer F, Bjørnland T, Nicklasson A, Becktor JP, Andersson G. Os- teonecrosis of the jaw in patients treated with oral and intra- venous bisphosphonates: experience in Sweden. Oral Surg Oral Med Oral Pathol Oral Radiol 118:202-8, 2014
Hayashida S, Soutome S, Yanamoto S, Fujita S, Hasegawa T, Komori T, Kojima Y, Miyamoto H, Shibuya Y, Ueda N, Kirita T, Nakahara H, Shinohara M, Umeda M. Evaluation of the Treatment Strate- gies for Medication-Related Osteonecrosis of the Jaws (MRONJ) and the Factors Affecting Treatment Outcome: A Multicenter Retrospective Study with Propensity Score Matching Analysis. J Bone Miner Res 32:2022-2029, 2017
Henien M, Carey B, Hullah E, Sproat C, Patel V. Methotrexate-asso- ciated osteonecrosis of the jaw: A report of two cases. Oral Surg Oral Med Oral Pathol Oral Radiol. doi: 10.1016/j.oooo. 2017.09.005, 2017
Hinson AM, Siegel ER, Stack BC Jr. Temporal correlation between bisphosphonate termination and symptom resolution in osteonecrosis of the jaw: a pooled case report analysis. J Oral Max- illofac Surg 73:53-62, 2015
Hoefert S, Hoefert CS, Albert M, Munz A, Grimm M, Northoff H, Reinert S, Alexander D. Zoledronate but not denosumab sup- presses macrophagic differentiation of THP-1 cells. An aetiologic model of bisphosphonate-related osteonecrosis of the jaw (BRONJ). Clin Oral Investig 19:1307-18, 2015
Hoefert S, Sade Hoefert C, Munz A, Schmitz I, Grimm M, Yuan A, Northoff H, Reinert S, Alexander D. Effect of bisphosphonates on macrophagic THP-1 cell survival in bisphosphonate-related osteonecrosis of the jaw (BRONJ). Oral Surg Oral Med Oral Pathol Oral Radiol 121:222-32, 2016
Hoefert S, Yuan A, Munz A, Grimm M, Elayouti A, Reinert S. Clinical course and therapeutic outcomes of operatively and non-oper- atively managed patients with denosumab-related osteonecrosis of the jaw (DRONJ). J Craniomaxillofac Surg 45:570-578, 2017
Kämmerer PW, Thiem D, Eisenbeiß C, Dau M, Schulze RK, Al-Nawas B, Draenert FG. Surgical evaluation of panoramic radiography and cone beam computed tomography for therapy planning of bisphosphonate-related osteonecrosis of the jaws. Oral Surg Oral Med Oral Pathol Oral Radiol 121:419-24, 2016
Kang B, Cheong S, Chaichanasakul T, Bezouglaia O, Atti E, Dry SM, Pirih FQ, Aghaloo TL, Tetradis S. Periapical disease and bispho- sphonates induce osteonecrosis of the jaws in mice. J Bone Miner Res 28:1631-40, 2013
Keribin P, Guerrot D, Jardin F, Moizan H. Osteonecrosis of the Jaw in a Patient Presenting With Post-Transplantation Lymphopro- liferative Disorder Treated With Rituximab: A Case Report. J Oral Maxillofac Surg doi: 10.1016/j.joms.2017.05.016, 2017
Khan AA, Morrison A, Hanley DA, Felsenberg D, McCauley LK, O'Ryan F, Reid IR, Ruggiero SL, Taguchi A, Tetradis S, Watts NB, Brandi ML, Peters E, Guise T, Eastell R, Cheung AM, Morin SN, Masri B, Cooper C, Morgan SL, Obermayer-Pietsch B, Lang- dahl BL, Al Dabagh R, Davison KS, Kendler DL, Sándor GK, Josse RG, Bhandari M, El Rabbany M, Pierroz DD, Sulimani R, Saun- ders DP, Brown JP, Compston J; International Task Force on Os- teonecrosis  of  the  Jaw.  Diagnosis  and  management  of  os- teonecrosis of the jaw: a systematic review and international consensus. J Bone Miner Res 30:3-23, 2015
Kim DW, Jung YS, Park HS, Jung HD. Osteonecrosis of the jaw re- lated to everolimus: a case report. Br J Oral Maxillofac Surg 51:e302-4, 2013
Kim HY, Lee SJ, Kim SM, Myoung H, Hwang SJ, Choi JY, Lee JH, Choung PH, Kim MJ, Seo BM. Extensive Surgical Procedures Re- sult in Better Treatment Outcomes for Bisphosphonate-Related Osteonecrosis of the Jaw in Patients With Osteoporosis. J Oral Maxillofac Surg 75:1404-1413, 2017
Kim JW, Landayan ME, Lee JY, Tatad JC, Kim SJ, Kim MR, Cha IH. Role of microcracks in the pathogenesis of bisphosphonate-re- lated osteonecrosis of the jaw. Clin Oral Investig 20:2251-2258, 2016
Kim SM, Eo MY, Kim YS, Lee SK. Histochemical observation of bony reversal lines in bisphosphonate-related osteonecrosis of the jaw. Oral Surg Oral Med Oral Pathol Oral Radiol 123:220-228, 2017
Klingelhöffer C, Klingelhöffer M, Müller S, Ettl T, Wahlmann U. Can dental panoramic radiographic findings serve as indicators for the development of medication-related osteonecrosis of the jaw? Dentomaxillofac Radiol 45:20160065, 2016a
Klingelhöffer C, Zeman F, Meier J, Reichert TE, Ettl T. Evaluation of surgical outcome and influencing risk factors in patients with medication-related osteonecrosis of the jaws. J Craniomaxillofac Surg 44:1694-1699, 2016b
Koerdt S, Dax S, Grimaldi H, Ristow O, Kuebler AC, Reuther T. Histomorphologic characteristics of bisphosphonate-related os- teonecrosis of the jaw. J Oral Pathol Med 43:448-53, 2014
Kolokythas A, Karras M, Collins E, Flick W, Miloro M, Adami G. Sali- vary Biomarkers Associated With Bone Deterioration in Patients With Medication-Related Osteonecrosis of the Jaws. J Oral Max- illofac Surg 73:1741-7, 2015
Koth VS, Figueiredo MA, Salum FG, Cherubini K. Bisphosphonate- related osteonecrosis of the jaw: from the sine qua non condi- tion of bone exposure to a non-exposed BRONJ entity. Den- tomaxillofac Radiol 45:20160049, 2016
Kumar V, Sinha RK. Bisphosphonate Related Osteonecrosis of the Jaw: An Update. J Maxillofac Oral Surg 13:386-93, 2014
Lee SH, Chang SS, Lee M, Chan RC, Lee CC. Risk of osteonecrosis in patients taking bisphosphonates for prevention of osteoporo- sis: a systematic review and meta-analysis. Osteoporos Int 25:1131-9, 2014
Lescaille G, Coudert AE, Baaroun V, Ostertag A, Charpentier E, Javelot MJ, Tolédo R, Goudot P, Azérad J, Berdal A, Spano JP, Ruhin B, Descroix V. Clinical study evaluating the effect of be- vacizumab on the severity of zoledronic acid-related os- teonecrosis of the jaw in cancer patients. Bone 58:103-7, 2014 Lombard T, Neirinckx V, Rogister B, Gilon Y, Wislet S. Medication- Related Osteonecrosis of the Jaw: New Insights into Molecular Mechanisms and Cellular Therapeutic Approaches. Stem Cells
Int 2016:8768162, 2016
Marx RE. Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic. J Oral Max- illofac Surg 61:1115-7, 2003
Mawardi H, Enzinger P, McCleary N, Manon R, Villa A, Treister N, Woo SB. Osteonecrosis of the jaw associated with ziv-afliber- cept. J Gastrointest Oncol 7:E81-E87, 2016
Mehrotra B. Antiresorptive Therapies for the Treatment of Malignant Osteolytic Bone Disease. Oral Maxillofac Surg Clin North Am 27:561-6, 2015
Melakopoulos I, Patrikiou A. BISPHOSPHONATE RELATED OS- TEONECROSIS OF THE JAWS. STOMATOLOGIA 65:3-12,
2008 (in Greek)
Migliorati CA, Mattos K, Palazzolo MJ. How patients' lack of knowl- edge about oral bisphosphonates can interfere with medical and dental care. J Am Dent Assoc 141:562-6, 2010
Morita M, Iwasaki R, Sato Y, Kobayashi T, Watanabe R, Oike T, Naka- mura S, Keneko Y, Miyamoto K, Ishihara K, Iwakura Y, Ishii K, Matsumoto M, Nakamura M, Kawana H, Nakagawa T, Miyamoto
T. Elevation of pro-inflammatory cytokine levels following anti- resorptive drug treatment is required for osteonecrosis devel- opment in infectious osteomyelitis. Sci Rep 7:46322, 2017
Movila A, Mawardi H, Nishimura K, Kiyama T, Egashira K, Kim JY, Villa A, Sasaki H, Woo SB, Kawai T. Possible pathogenic engagement of soluble Semaphorin 4D produced by γδT cells in medication- related osteonecrosis of the jaw (MRONJ). Biochem Biophys Res Commun 480:42-47, 2016
Nikitakis N, Kamperos G, Sklavounou – Andrikopoulou A. Bisphos- phonate-induced osteonecrosis of the jaws: Prevention and management. ARCHIVES OF HELLENIC MEDICINE 26:583-
592, 2009 (in Greek)
Otto  S,  Tröltzsch  M,  Jambrovic  V,  Panya  S,  Probst  F,  Ristow  O, Ehrenfeld M, Pautke C. Tooth extraction in patients receiving oral or intravenous bisphosphonate administration: A trigger for BRONJ development? J Craniomaxillofac Surg 43:847-54, 2015
Palla B, Burian E, Klecker JR, Fliefel R, Otto S. Systematic review of oral ulceration with bone sequestration. J Craniomaxillofac Surg 44:257-64, 2016
Panya S, Fliefel R, Probst F, Tröltzsch M, Ehrenfeld M, Schubert S, Otto S. Role of microbiological culture and polymerase chain reaction (PCR) of actinomyces in medication-related os- teonecrosis  of  the  jaw  (MRONJ).  J  Craniomaxillofac  Surg 45:357-363, 2017
Patel S, Choyee S, Uyanne J, Nguyen AL, Lee P, Sedghizadeh PP, Kumar SK, Lytle J, Shi S, Le AD. Non-exposed bisphosphonate- related osteonecrosis of the jaw: a critical assessment of current definition, staging, and treatment guidelines. Oral Dis 18:625-32, 2012
Patel V, Sproat C, Kwok J, Tanna N. Axitinib-related osteonecrosis of the jaw. Oral Surg Oral Med Oral Pathol Oral Radiol 124:e257-e260, 2017
Pichardo SE, van Merkesteyn JP. Evaluation of a surgical treatment of denosumab-related osteonecrosis of the jaws. Oral Surg Oral Med Oral Pathol Oral Radiol 122:272-8, 2016
Pushalkar S, Li X, Kurago Z, Ramanathapuram LV, Matsumura S, Fleisher KE, Glickman R, Yan W, Li Y, Saxena D. Oral microbiota and host innate immune response in bisphosphonate-related os- teonecrosis of the jaw. Int J Oral Sci 6:219-26, 2014
Reich W, Bilkenroth U, Schubert J, Wickenhauser C, Eckert AW. Sur- gical treatment of bisphosphonate-associated osteonecrosis: Prognostic score and long-term results. J Craniomaxillofac Surg 43:1809-22, 2015
Ripamonti CI, Maniezzo M, Campa T, Fagnoni E, Brunelli C, Saibene G, Bareggi C, Ascani L, Cislaghi E. Decreased occurrence of os- teonecrosis of the jaw after implementation of dental preventive measures in solid tumour patients with bone metastases treated with bisphosphonates. The experience of the National Cancer Institute of Milan. Ann Oncol 20:137-45, 2009
Ristow O, Gerngroß C, Schwaiger M, Hohlweg-Majert B, Kehl V, Jansen H, Hahnefeld L, Koerdt S, Otto S, Pautke C. Effect of an- tiresorptive drugs on bony turnover in the jaw: denosumab compared with bisphosphonates. Br J Oral Maxillofac Surg 52:308-13, 2014
Rollason V, Laverrière A, MacDonald LC, Walsh T, Tramèr MR, Vogt- Ferrier NB. Interventions for treating bisphosphonate-related osteonecrosis of the jaw (BRONJ). Cochrane Database Syst Rev 26;2:CD008455, 2016
Ruggiero SL, Dodson TB, Fantasia J, Goodday R, Aghaloo T, Mehro- tra B, O'Ryan F; American Association of Oral and Maxillofacial Surgeons. American Association of Oral and Maxillofacial Sur- geons position paper on medication-related osteonecrosis of the jaw-2014 update. J Oral Maxillofac Surg 72:1938-56, 2014
Ruggiero SL, Kohn N. Disease Stage and Mode of Therapy Are Im- portant Determinants of Treatment Outcomes for Medication- Related Osteonecrosis of the Jaw. J Oral Maxillofac Surg 73:S94- S100, 2015
Ruggiero SL. Diagnosis and Staging of Medication-Related Os- teonecrosis of the Jaw. Oral Maxillofac Surg Clin North Am 27:479-87, 2015
Santos-Silva AR, Belizário Rosa GA, Castro Júnior Gd, Dias RB, Prado Ribeiro AC, Brandão TB. Osteonecrosis of the mandible asso- ciated with bevacizumab therapy. Oral Surg Oral Med Oral Pathol Oral Radiol 115:e32-6, 2013
Schiodt M, Reibel J, Oturai P, Kofod T. Comparison of nonexposed and exposed bisphosphonate-induced osteonecrosis of the jaws: a retrospective analysis from the Copenhagen cohort and a pro- posal for an updated classification system. Oral Surg Oral Med Oral Pathol Oral Radiol 117:204-13, 2014
Shintani T, Hayashido Y, Mukasa H Akagi E, Hoshino M, Ishida Y, Hamana T, Okamoto K, Kanda T, Koizumi K, Yoshioka Y, Tani R, Toratani S, Okamoto T. Comparison of the prognosis of bis- phosphonate-related osteonecrosis of the jaw caused by oral and intravenous bisphosphonates. Int J Oral Maxillofac Surg 44:840-4, 2015
Smidt-Hansen T, Folkmar TB, Fode K, Agerbaek M, Donskov F. Com- bination of zoledronic Acid and targeted therapy is active but may induce osteonecrosis of the jaw in patients with metastatic renal cell carcinoma. J Oral Maxillofac Surg 71:1532-40, 2013
Soundia A, Hadaya D, Esfandi N, de Molon RS, Bezouglaia O, Dry SM, Pirih FQ, Aghaloo T, Tetradis S. Osteonecrosis of the jaws (ONJ) in mice after extraction of teeth with periradicular dis- ease. Bone 90:133-41, 2016
Soundia A, Hadaya D, Esfandi N, Gkouveris I, Christensen R, Dry SM, Bezouglaia O, Pirih F, Nikitakis N, Aghaloo T, Tetradis S. Zoledronate Impairs Socket Healing after Extraction of Teeth with Experimental Periodontitis. J Dent Res doi: 10.1177/0022034517732770, 2017
Stockmann P, Hinkmann FM, Lell MM, Fenner M, Vairaktaris E, Neukam FW, Nkenke E. Panoramic radiograph, computed to- mography or magnetic resonance imaging. Which imaging tech- nique should be preferred in bisphosphonate-associated os- teonecrosis of the jaw? A prospective clinical study. Clin Oral Investig 14:311-7, 2010
Sun J, Wen X, Jin F, Li Y, Hu J, Sun Y. Bioinformatics analyses of dif- ferentially expressed genes associated with bisphosphonate-re- lated osteonecrosis of the jaw in patients with multiple myeloma. Onco Targets Ther 8:2681-8, 2015
Tanna N, Steel C, Stagnell S, Bailey E. Awareness of medication re- lated osteonecrosis of the jaws (MRONJ) amongst general den- tal practitioners. Br Dent J 222:121-125, 2017
Thumbigere-Math V, Michalowicz BS, de Jong EP, Griffin TJ, Basi DL, Hughes PJ, Tsai ML, Swenson KK, Rockwell L, Gopalakrishnan R. Salivary proteomics in bisphosphonate-related osteonecrosis of the jaw. Oral Dis 21:46-56, 2015
Thumbigere-Math V, Michalowicz BS, Hodges JS, Tsai ML, Swenson KK, Rockwell L, Gopalakrishnan R. Periodontal disease as a risk factor for bisphosphonate-related osteonecrosis of the jaw. J Pe- riodontol 85:226-33, 2014
Thumbigere-Math V, Michalowicz BS, Hughes PJ, Basi DL, Tsai ML, Swenson KK, Rockwell L, Gopalakrishnan R. Serum Markers of Bone Turnover and Angiogenesis in Patients With Bisphospho- nate-Related Osteonecrosis of the Jaw After Discontinuation of Long-Term Intravenous Bisphosphonate Therapy. J Oral Max- illofac Surg 74:738-46, 2016
Troeltzsch M, Cagna D, Stähler P, Probst F, Kaeppler G, Troeltzsch M, Ehrenfeld M, Otto S. Clinical features of peri-implant med- ication-related osteonecrosis of the jaw: Is there an associa- tion to peri-implantitis? J Craniomaxillofac Surg 44:1945-1951, 2016
Tsetsenekou E, Kalyvas D. New insights into the mechanisms of bis- phosphonates action. Hellenic Archives of Oral & Maxillofacial Surgery 3: 157-166, 2010
Ulmner M, Jarnbring F, Törring O. Osteonecrosis of the jaw in Swe- den associated with the oral use of bisphosphonate. J Oral Max- illofac Surg 72:76-82, 2014
van Cann T, Loyson T, Verbiest A, Clement PM, Bechter O, Willems L, Spriet I, Coropciuc R, Politis C, Vandeweyer RO1, Schoenaers J, Debruyne PR, Dumez H, Berteloot P, Neven P, Nackaerts K, Woei-A-Jin FJSH, Punie K, Wildiers H, Beuselinck B. Incidence of medication-related osteonecrosis of the jaw in patients treated with both bone resorption inhibitors and vascular en- dothelial growth factor receptor tyrosine kinase inhibitors. Sup- port Care Cancer doi: 10.1007/s00520-017-3903-5, 2017
Vasconcelos AC, de Azambuja Berti-Couto S, Figueiredo MA, Salum FG, Lopes TG, Cherubini K. Laboratory methods and biomark- ers in the evaluation of bisphosphonate effects on body tissues: a literature review. J Oral Pathol Med 42:577-86, 2013
Viviano M, Rossi M, Cocca S. A rare case of osteonecrosis of the jaw related to imatinib. J Korean Assoc Oral Maxillofac Surg 43:120- 124, 2017
Williams WB, O'Ryan F. Management of Medication-Related Os- teonecrosis of the Jaw. Oral Maxillofac Surg Clin North Am 27:517-25, 2015
Yarom N, Lazarovici TS, Whitefield S, Weissman T, Wasserzug O, Yahalom R. Rapid onset of osteonecrosis of the jaw in patients switching from bisphosphonates to denosumab. Oral Surg Oral Med Oral Pathol Oral Radiol doi: 10.1016/j.oooo.2017.09.014, 2017
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          • HYBRID VERRUCUS CARCINOMA OF THE ORAL CAVITY: A CASE REPORT AND REVIEW OF THE LITERATURE
          • A COMPARISON OF GBR MEMBRANES
          • A RARE CASE OF CERVICAL CYSTIC LYMPHANGIOMA IN AN ADULT PATIENT
          • ΟSSEODENSIFICATION. A PROMISING NEW TECHNIQUE.
          • PERFORATION OF SINUS MEMBRANE DURING SINUS FLOOR ELEVATION: REPAIR WITH COLLAGEN MEMBRANE AND METHOD RELIABILITY
          • “LIP SHAVE” TECHNIQUE: LITERATURE REVIEW AND CASE PRESENTATION
          • IMPLANT PLACEMENT WITH SIMULTANEOUS SINUS FLOOR ELEVATION IN THE PRESENCE OF A LARGE SINUS MUCOCELE: A CASE REPORT
          • Foundation of the posterior occlusal support of the osseointergrated prostheses on the remaining residual ridge.
          • Dental implants surgery and systematic diseases
          • Nasal reconstruction after skin cancer surgery; presentation of treatment modalities for medically compromised patients.
          • “STICKY TOOTH”. SOCKET PRESERVATION BY USING AN AUTOLOGOUS DENTINE GRAFT IN COMBINATION WITH PLASMA RICH FIBRIN. CASE REPORT AND A TWO YEARS FOLLOW UP.
          • Immunomodulatory effects of Nd:YAG (1064 nm) and diode laser (810 nm) wavelengths to LPS-challenged human gingival fibroblasts
          • Is aseptic bone necrosis a cause for early implant failure in patients with metal allergies? – A case report and literature review
          • CLINICAL APPLICATIONS OF SAFESCRAPER® IN MAXILLARY SINUS FLOOR ELEVATION AND RIDGE AUGMENTATION
          • A novel crestal protocol for the application of denatured Albumin in minimally invasive Implantology and Sinus Piezosurgery - Preliminary Results of a Pilot Study
          • Lateral cephalometric changes and stability of BSSO versus IVRO for mandibular setback surgery: A systematic review and meta-analysis.
          • BONE REGENERATION FOR DENTAL IMPLANT PLACEMENT: A 5-YEAR RETROSPECTIVE STUDY OF 358 CASES
    • Volume 22 >
      • HAOMS Vol.22, Issue 1 >
        • HAOMS (2021) 1, 5-11
        • HAOMS (2021) 1, 13-17
        • HAOMS (2021) 1, 19-26
        • HAOMS (2021) 1, 27-36
        • HAOMS (2021) 1, 37-41
        • HAOMS (2021) 1, 43-48
      • HAOMS Vol.22, Issue 2 >
        • Editorial 2, 2021
        • HAOMS (2021) 2, 57-72
        • HAOMS (2021) 2, 73-85
        • HAOMS (2021) 2, 87-100
        • HAOMS (2021) 2, 101-108
        • HAOMS (2021) 2, 109-117
        • HAOMS (2021) 2, 119-124
        • HAOMS (2021) 2, 125-128
        • HAOMS (2021) 2, 129-134
      • HAOMS Vol.22, Issue 3 >
        • Editorial 3, 2021
        • HAOMS (2021) 3, 141-154
        • HAOMS (2021) 3, 155-164
        • HAOMS (2021) 3, 165-182
        • HAOMS (2021) 3, 183-192
        • HAOMS (2021) 3, 193-196
        • HAOMS (2021) 3, 197-202
        • HAOMS (2021) 3, 203-206
        • HAOMS (2021) 3, 207-212
    • Volume 21 >
      • HAOMS Vol.21, Issue 1 >
        • HAOMS (2020) 1, 1-9
        • HAOMS (2020) 1, 11-24
        • HAOMS (2020) 1, 25-32
        • HAOMS (2020) 1, 33-42
      • HAOMS Vol 21, Issue 2 >
        • HAOMS (2020) 2, 67-75
        • HAOMS (2020) 2, 77-83
        • HAOMS (2020) 2, 85-94
        • HAOMS (2020) 2, 95-102
      • HAOMS Vol 21, Issue 3 >
        • HAOMS (2020) 3, 117-126
        • HAOMS (2020) 3, 127-133
        • HAOMS (2020) 3, 135-141
        • HAOMS (2020) 3, 143-159
    • Volume 20 >
      • HAOMS Vol.20, Issue 1 >
        • HAOMS (2019) 1, 1-6
        • HAOMS (2019) 1, 7-11
        • HAOMS (2019) 1, 13-23
        • HAOMS (2019) 1, 25-36
      • HAOMS Vol.20, Issue 2 >
        • HAOMS (2019) 2, 49-56
        • HAOMS (2019) 2, 57-64
        • HAOMS (2019) 2, 65-68
        • HAOMS (2019) 2, 69-68
      • HAOMS Vol.20, Issue 3 >
        • HAOMS (2019) 3, 103-111
        • HAOMS (2019) 3, 113-117
        • HAOMS (2019) 3, 119-126
        • HAOMS (2019) 3, 127-132
    • Volume 19 >
      • Vol.19, Issue 1 >
        • HAOMS (2018) 1, 3-10
        • HAOMS (2018) 1, 11-34
        • HAOMS (2018) 1, 35-42
        • HAOMS (2018) 1, 43-50
      • Vol.19, Issue 2 >
        • HAOMS (2018) 2, 59-88
        • HAOMS (2018) 2, 89-104
        • HAOMS (2018) 2, 105-124
        • HAOMS (2018) 2, 125-138
      • Vol.19, Issue 3 >
        • HAOMS (2018) 3, 151-157
        • HAOMS (2018) 3, 159-166
        • HAOMS (2018) 3, 167-182
        • HAOMS (2018) 3, 183-187
    • Volume 18 >
      • Vol.18, Issue 1 >
        • HAOMS (2017) 1, 1-8
        • HAOMS (2017) 1, 9-19
        • HAOMS (2017) 1, 21-26
        • HAOMS (2017) 1, 27-36
      • Vol.18, Issue 2 >
        • HAOMS (2017) 2, 47-56
        • HAOMS (2017) 2, 57-78
        • HAOMS (2017) 2, 79-90
        • HAOMS (2017) 2, 91-98
      • Vol.18, Issue 3 >
        • HAOMS (2017) 3, 109-114
        • HAOMS (2017) 3, 115-128
        • HAOMS (2017) 3, 129-162
        • HAOMS (2017) 3, 163-168
    • Volume 17 >
      • Vol.17, Issue 1 >
        • HAOMS (2016) 1, 5-11
        • HAOMS (2016) 1, 13-20
        • HAOMS (2016) 1, 21-26
        • HAOMS (2016) 1, 27-33
        • HAOMS (2016) 1, 35-42
      • Vol.17, Issue 2 >
        • HAOMS (2016) 2, 49-62
        • HAOMS (2016) 2, 63-76
        • HAOMS (2016) 2, 77-87
        • HAOMS (2016) 2, 89-97
      • Vol.17, Issue 3 >
        • HAOMS (2016) 3, 107-114
        • HAOMS (2016) 3, 115-124
        • HAOMS (2016) 3, 125-141
        • HAOMS (2016) 3, 143-156
    • Volume 16 >
      • Vol.16, Issue 1 >
        • HAOMS (2015) 1, 3-10
        • HAOMS (2015) 1, 11-16
        • HAOMS (2015) 1, 17-22
        • HAOMS (2015) 1, 23-29
        • HAOMS (2015) 1, 31-42
      • Vol.16, Issue 2 >
        • HAOMS (2015) 2, 49-56
        • HAOMS (2015) 2, 57-63
        • HAOMS (2015) 2, 63-70
        • HAOMS (2015) 2, 71-81
        • HAOMS (2015) 2, 83-96
      • Vol.16, Issue 3 >
        • HAOMS (2015) 3, 103-118
        • HAOMS (2015) 3, 119-128
        • HAOMS (2015) 3, 129-136
        • HAOMS (2015) 3, 137-146
        • HAOMS (2015) 3, 147-166
    • Volume 15 >
      • Vol.15, Issue 1 >
        • HAOMS (2014) 1, 1-10
        • HAOMS (2014) 1, 11-18
        • HAOMS (2014) 1, 19-25
        • HAOMS (2014) 1, 27-36
        • HAOMS (2014) 1, 37-43
      • Vol.15, Issue 2 >
        • HAOMS (2014) 2, 51-58
        • HAOMS (2014) 2, 59-64
        • HAOMS (2014) 2, 65-76
        • HAOMS (2014) 2, 77-86
        • HAOMS (2014) 2, 87-100
      • Vol.15, Issue 3 >
        • HAOMS (2014) 3, 107-120
        • HAOMS (2014) 3, 121-132
        • HAOMS (2014) 3, 133-139
        • HAOMS (2014) 3, 141-147
        • HAOMS (2014) 3, 149-158
    • Volume 14 >
      • Vol.14, Issue 1 >
        • HAOMS (2013) 1, 1-14
        • HAOMS (2013) 1, 15-24
        • HAOMS (2013) 1, 25-33
        • HAOMS (2013) 1, 35-46
        • HAOMS (2013) 1, 47-52
      • Vol.14, Issue 2 >
        • HAOMS (2013) 2, 63-74
        • HAOMS (2013) 2, 75-83
        • HAOMS (2013) 2, 85-95
        • HAOMS (2013) 2, 99-106
        • HAOMS (2013) 2, 107-112
        • HAOMS (2013) 2, 113-117
      • Vol.14, Issue 3 >
        • HAOMS (2013) 3, 131-142
        • HAOMS (2013) 3, 143-152
        • HAOMS (2013) 3, 153-158
        • HAOMS (2013) 3, 159-168
        • HAOMS (2013) 3, 169-182
    • Volume 13 >
      • Vol.13, Issue 1 >
        • HAOMS (2012) 1, 3-20
        • HAOMS (2012) 1, 21-32
        • HAOMS (2012) 1, 33-40
        • HAOMS (2012) 1, 41-48
        • HAOMS (2012) 1, 49-54
        • HAOMS (2012) 1, 55-61
      • Vol.13, Issue 2 >
        • HAOMS (2012) 2, 71-81
        • HAOMS (2012) 2, 83-91
        • HAOMS (2012) 2, 93-98
        • HAOMS (2012) 2, 99-106
        • HAOMS (2012) 2, 107-114
        • HAOMS (2012) 2, 115-121
      • Vol.13, Issue 3 >
        • HAOMS (2012) 3, 131-143
        • HAOMS (2012) 3, 145-150
        • HAOMS (2012) 3, 151-158
        • HAOMS (2012) 3, 159-166
        • HAOMS (2012) 3, 167-173
    • Volume 12 >
      • Vol.12, Issue 1 >
        • HAOMS (2011) 1, 1-14
        • HAOMS (2011) 1, 15-25
        • HAOMS (2011) 1, 27-35
        • HAOMS (2011) 1, 37-43
        • HAOMS (2011) 1, 45-51
      • Vol.12, Issue 2 >
        • HAOMS (2011) 2, 63-78
        • HAOMS (2011) 2, 79-92
        • HAOMS (2011) 2, 93-100
        • HAOMS (2011) 2, 101-111
        • HAOMS (2011) 2, 113-120
        • HAOMS (2011) 2, 121-127
      • Vol.12, Issue 3 >
        • HAOMS (2011) 3, 141-154
        • HAOMS (2011) 3, 155-164
        • HAOMS (2011) 3, 165-178
        • HAOMS (2011) 3, 179-187
        • HAOMS (2011) 3, 189-193
    • Volume 11 >
      • Vol.11, Issue 1 >
        • HAOMS (2010) 1, 3-14
        • HAOMS (2010) 1, 15-24
        • HAOMS (2010) 1, 25-32
        • HAOMS (2010) 1, 33-37
        • HAOMS (2010) 1, 39-47
      • Vol.11, Issue 2 >
        • HAOMS (2010) 2, 57-68
        • HAOMS (2010) 2, 69-81
        • HAOMS (2010) 2, 83-90
        • HAOMS (2010) 2, 91-104
        • HAOMS (2010) 2, 105-111
      • Vol.11, Issue 3 >
        • HAOMS (2010) 3, 121-128
        • HAOMS (2010) 3, 129-139
        • HAOMS (2010) 3, 141-156
        • HAOMS (2010) 3, 157-166
        • HAOMS (2010) 3, 167-173
    • Volume 10 >
      • Vol.10, Issue 1
      • Vol.10, Issue 2
      • Vol.10, Issue 3
    • Volume 9 >
      • Vol.9, Issue 1
      • Vol.9, Issue 2
      • Vol.9, Issue 3
    • Volume 8
    • Volume 7 >
      • Vol.7, Issue 1
      • Vol.7, Issue 2
      • Vol.7, Issue 3
      • Vol.7, Issue 4
    • Volume 6 >
      • Vol.6, Issue 1
    • Volume 5
    • Volume 4
    • Volume 3
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