Multiple brown tumors in maxillary bones as the only symptom of hyperparathyroidism: Report of a case and review of the literature
Álvaro RANZ, Eduardo SÁNCHEZ-JÁUREGUI, Álvaro PASTOR, Rosario CARRILLO, Julio ACERO
Department of Oral and Maxillofacial surgery, Ramon y Cajal University Hospital, Madrid, Spain (Head: Professor J. Acero)
Hellenic Archives of Oral & Maxillofacial Surgery (2018) 3, 183-187
SUMMARY: In this paper, we report a clinical case of a 17-year-old woman with multiple asymptomatic, radiolucent lesions of the maxillofacial bones. Histological result of the lesion was giant cell granuloma. A blood test was recommended in order to confirm or exclude the diagnosis of hyperparathyroidism. The results showed a total serum calcium level of 15.1 mg/dl and a Parathormone (PTH) level of 1,155 pg/ml, thus confirming the diagnosis of primary hyperparathyroidism.
KEY WORDS: Maxilla brown tumor, mandible brown tumor, multiple giant cell granuloma, primary hyper-parathyroidism
REFERENCES
Brabyn P, Capote A, Belloti M, Zylberberg I: Hyperparathyroidism Di- agnosed Due to Brown Tumors of the Jaw: A Case Report and Literature Review. J Oral Maxillofac Surg 75: 2162-2169, 2017
Curtis NJ, Walker DM: A case of aggressive multiple metachronous central giant cell granulomas of the jaws: differential diagnosis and management options. Int J Oral Maxillofac Surg 34(7): 806-8, 2005 Kang MS, Kim HJ: Multiple synchronous central giant cell of the max- illofacial region: a case report. J Korean Soc Radiol 62: 11-15, 2010 Keyser JS, Postma GN: Brown tumor of the mandible. Am J Otolaryn-
gol 17: 407–410, 2005
Miloro M, Quinn PD: Synchronous Central Giant Cell Lesions of the Jaws: Report of a Case and Review of the Literature. J Oral Max- illofacial Surg 53: 1350-55,1995
Mittal S, Naseem I, Akhtar K, Ahmad I, Khalid M: Multifocal giant cell reparative granuloma involving maxilla and mandible: a rare entity. Ann Saudi Med 35(4): 321-323, 2015
Mori H, Okada Y, Arao T, Shimaziri S, Tanaka Y: A case of multiple brown tumors with primary hyperparathyroidism. J Bone Miner Metab 31 :123–127, 2013
Rai S, Rattan V, Bhadada SK: Giant Cell Lesions Associated with Primary Hyperparathyroidism. J Maxillofac Oral Surg 14(4): 930–934, 2015 Robinson RA, Vincent SD: Afip Atlas Of Tumor Pathology. 4th series, Vol. 16. Tumors and Cysts of the Jaws. 4th edition, American Reg-
istry Of Pathology, Silver Spring, Maryland, 2012
Rosenberg EH, Guralnick WC: Hyperparathyroidism: A review of 220 proved cases, with special emphasis on findings in the jaws. Oral Surg 15:83, 1962
Sandhya T, Avinash T, Snehal D, Neha T, Uma M: Multifocal Central Giant Cell Granuloma - A Case Report. Iran J Pathol 11(3): 276– 280, 2016
Triantafillidou K, Zouloumis L, Karakinaris G, Kalimeras E, Iordanidis F: Brown tumors of the jaws associated with primary or secondary hyperparathyroidism. A clinical study and review of the literature. Am J Otolaryngol 27(4): 281-6, 2006
Department of Oral and Maxillofacial surgery, Ramon y Cajal University Hospital, Madrid, Spain (Head: Professor J. Acero)
Hellenic Archives of Oral & Maxillofacial Surgery (2018) 3, 183-187
SUMMARY: In this paper, we report a clinical case of a 17-year-old woman with multiple asymptomatic, radiolucent lesions of the maxillofacial bones. Histological result of the lesion was giant cell granuloma. A blood test was recommended in order to confirm or exclude the diagnosis of hyperparathyroidism. The results showed a total serum calcium level of 15.1 mg/dl and a Parathormone (PTH) level of 1,155 pg/ml, thus confirming the diagnosis of primary hyperparathyroidism.
KEY WORDS: Maxilla brown tumor, mandible brown tumor, multiple giant cell granuloma, primary hyper-parathyroidism
REFERENCES
Brabyn P, Capote A, Belloti M, Zylberberg I: Hyperparathyroidism Di- agnosed Due to Brown Tumors of the Jaw: A Case Report and Literature Review. J Oral Maxillofac Surg 75: 2162-2169, 2017
Curtis NJ, Walker DM: A case of aggressive multiple metachronous central giant cell granulomas of the jaws: differential diagnosis and management options. Int J Oral Maxillofac Surg 34(7): 806-8, 2005 Kang MS, Kim HJ: Multiple synchronous central giant cell of the max- illofacial region: a case report. J Korean Soc Radiol 62: 11-15, 2010 Keyser JS, Postma GN: Brown tumor of the mandible. Am J Otolaryn-
gol 17: 407–410, 2005
Miloro M, Quinn PD: Synchronous Central Giant Cell Lesions of the Jaws: Report of a Case and Review of the Literature. J Oral Max- illofacial Surg 53: 1350-55,1995
Mittal S, Naseem I, Akhtar K, Ahmad I, Khalid M: Multifocal giant cell reparative granuloma involving maxilla and mandible: a rare entity. Ann Saudi Med 35(4): 321-323, 2015
Mori H, Okada Y, Arao T, Shimaziri S, Tanaka Y: A case of multiple brown tumors with primary hyperparathyroidism. J Bone Miner Metab 31 :123–127, 2013
Rai S, Rattan V, Bhadada SK: Giant Cell Lesions Associated with Primary Hyperparathyroidism. J Maxillofac Oral Surg 14(4): 930–934, 2015 Robinson RA, Vincent SD: Afip Atlas Of Tumor Pathology. 4th series, Vol. 16. Tumors and Cysts of the Jaws. 4th edition, American Reg-
istry Of Pathology, Silver Spring, Maryland, 2012
Rosenberg EH, Guralnick WC: Hyperparathyroidism: A review of 220 proved cases, with special emphasis on findings in the jaws. Oral Surg 15:83, 1962
Sandhya T, Avinash T, Snehal D, Neha T, Uma M: Multifocal Central Giant Cell Granuloma - A Case Report. Iran J Pathol 11(3): 276– 280, 2016
Triantafillidou K, Zouloumis L, Karakinaris G, Kalimeras E, Iordanidis F: Brown tumors of the jaws associated with primary or secondary hyperparathyroidism. A clinical study and review of the literature. Am J Otolaryngol 27(4): 281-6, 2006
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