Bone morphogenetic protein 2 (BMP-2) expression in benign salivary gland
tumours
Panagiotis CHRYSSOLOURIS, Constantinos ALEXANDRIDIS, Alexandra SKLAVOUNOU, Sofia TSELENI-BALAFOUTA
A΄ Pathologic Anatomy Laboratory, Athens Medical School (Head: Professor E. Patsouris)
Hellenic Archives of Oral & Maxillofacial Surgery (2013) 1, 25-33
SUMMARY: Bone morphogenetic proteins (BMPs) play a significant role in the process of carcinogenesis, participating in neoangiogenesis, tumour metastatic behaviour and cancer stem cell regulation. However, their expression and role in the development of benign salivary gland tumours has so far been underresearched. Aim: The aim of this study is to examine BMP-2 expression in benign salivary gland tumours. Material: The material of this study included 97 specimens of benign parotid tumours (46 Warthin cystadenolymphomas and 51 pleomorphic adenomas) collected between 2000 and 2010 at the ‘‘Ippokrateion’’ General Hospital of Athens, from patients between 21 and 80 years old. Method: BMP-2 expression was determined by immunohistochemical staining with a specific antibody, using the avidin-biotin-peroxidase enzymic method. Results: Intra-cellular BMP-2 expression was observed in benign salivary gland tumours; it was significantly stronger in Warthin tumours than it was in pleomorphic adenomas. Conclusions: BMP-2 expression appears to be a determining factor in the development and behavioural patterns of both benign and malignant tumours.
KEY WORDS: Bone morphogenetic protein (BMP), epithelial-mucosal transitions, benign salivary gland tumours.
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