EVOLUTIONARY PROCESS OF THE ORAL CANCER: CORRELATION OF THE INFLAMMATORY MARKERS IN THE PERIPHERAL BLOOD WITH THE PRESENCE OF THE LYMPHOCYTE POPULATION IN THE NEOPLASTIC TISSUE.
Authors:
Louizakis A.1, Cheva A.2, Metallidis S.3, Christos T.2, Tatsis D.1, Paraskevopoulos K.1, Vahtsevanos K.1
Affiliation:
1 Oral Maxillofacial Surgery Department, G Papanikolaou Hospital, Aristotle University, Thessaloniki, Greece
2 Pathology Department, Faculty of Medicine, Aristotle University of Thessaloniki, University Campus, 54124 Thessaloniki, Greece
3 First Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA University Hospital, Thessaloniki, Greece
Doi: 10.54936/haoms242p48
ABSTRACT:
Objectives: This study aims to evaluate the relationship between systemic inflammation and the presence and stage of oral cancer development. The evaluation will be performed using a prospective analysis of 80 patients diagnosed with oral cancer between 2022 and 2025. The study combines both markers of inflammation in the peripheral blood and data of the lymphocyte identity in neoplastic tissue.
Materials and Methods: The inflammation markers tested include the total white blood cell (WBC) count and its ratio to neutrophils (NLR/WBC), monocytes (LMR/WBC) and platelets (PLR/WBC). In addition, C- reactive protein (CRP) and erythrocyte sedimentation rate (ESR) levels will be recorded. Immunohistochemistry will be performed on the neoplastic tissue to determine the presence of CD4+ and CD8+ tumor-infiltrating lymphocytes (TILs).
Results: Preliminary findings reveal that elevated NLR and PLR ratios in peripheral blood, as well as high levels of CRP and ESR, are strongly associated with advanced stages of oral cancer, indicating faster progression and increased likelihood of recurrence. Conversely, higher levels of LMR in blood and CD4+ and CD8+ TILs in cancer tissue are often associated with a more favorable prognosis. In addition, a decrease in NLR and PLR values is expected after cancer treatment. These findings will correlate to a tumor stage, according to TNM system.
Conclusion: In conclusion, the present study will shed light on the association between systemic inflammatory response and oral squamous cell carcinoma (OSCC), establishing a clear association between elevated peripheral blood inflammatory markers and advanced stages of cancer. In addition, we will investigate the infiltration of CD4+ and CD8+ TILs into neoplastic tissue to assess the host immune response to the tumor. These insights will contribute to a better understanding of the overall cancer development process and help to evaluate the overall therapeutic response.
KEY WORDS: Oral cancer, Inflammation markers, TILS
Authors:
Louizakis A.1, Cheva A.2, Metallidis S.3, Christos T.2, Tatsis D.1, Paraskevopoulos K.1, Vahtsevanos K.1
Affiliation:
1 Oral Maxillofacial Surgery Department, G Papanikolaou Hospital, Aristotle University, Thessaloniki, Greece
2 Pathology Department, Faculty of Medicine, Aristotle University of Thessaloniki, University Campus, 54124 Thessaloniki, Greece
3 First Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA University Hospital, Thessaloniki, Greece
Doi: 10.54936/haoms242p48
ABSTRACT:
Objectives: This study aims to evaluate the relationship between systemic inflammation and the presence and stage of oral cancer development. The evaluation will be performed using a prospective analysis of 80 patients diagnosed with oral cancer between 2022 and 2025. The study combines both markers of inflammation in the peripheral blood and data of the lymphocyte identity in neoplastic tissue.
Materials and Methods: The inflammation markers tested include the total white blood cell (WBC) count and its ratio to neutrophils (NLR/WBC), monocytes (LMR/WBC) and platelets (PLR/WBC). In addition, C- reactive protein (CRP) and erythrocyte sedimentation rate (ESR) levels will be recorded. Immunohistochemistry will be performed on the neoplastic tissue to determine the presence of CD4+ and CD8+ tumor-infiltrating lymphocytes (TILs).
Results: Preliminary findings reveal that elevated NLR and PLR ratios in peripheral blood, as well as high levels of CRP and ESR, are strongly associated with advanced stages of oral cancer, indicating faster progression and increased likelihood of recurrence. Conversely, higher levels of LMR in blood and CD4+ and CD8+ TILs in cancer tissue are often associated with a more favorable prognosis. In addition, a decrease in NLR and PLR values is expected after cancer treatment. These findings will correlate to a tumor stage, according to TNM system.
Conclusion: In conclusion, the present study will shed light on the association between systemic inflammatory response and oral squamous cell carcinoma (OSCC), establishing a clear association between elevated peripheral blood inflammatory markers and advanced stages of cancer. In addition, we will investigate the infiltration of CD4+ and CD8+ TILs into neoplastic tissue to assess the host immune response to the tumor. These insights will contribute to a better understanding of the overall cancer development process and help to evaluate the overall therapeutic response.
KEY WORDS: Oral cancer, Inflammation markers, TILS