Squamous odontogenic tumor-like proliferations: Report of 6 cases and review of the literature
Michail NIKOLAKIS, Evangelia PIPERI, Evanthia CHRYSOMALI, Nikolaos KEREZOUDIS, Konstantinos TOSIOS
Department of Endodontics (Head: Prof. M. Khabbaz) and Department of Oral Medicine (Head: Prof. A. Sklavounou), Dental School, National and Kapodistrian University of Athens, Greece
Hellenic Archives of Oral & Maxillofacial Surgery (2016) 1, 13-20
SUMMARY: Squamous odontogenic tumor-like prolifer- ations (SOTLPs) are epithelial nests located within the wall of odontogenic cysts and are histologically similar to the squamous odontogenic tumor.
Aim: To present the clinical and microscopical findings of 6 cases of SOTLPs and discuss their differential diagnosis. Materials and Methods: Six cases of SOTLPs in odonto- genic cysts were collected from the archives of the De- partment of Oral Pathology and Medicine, from January 1983 to December 2015.
Results: Five cases occurred in men and one in a woman, with a mean age of 42.5 yrs. Histologically, epithelial is- lands were observed within the connective tissue of the wall of the cysts, which in most cases were infiltrated by inflammatory cells.
Conclusions: SOTLPs constitute a hyperplasia of the ep- ithelial lining of odontogenic cysts and their presence does not affect the biological behavior of the cysts. Proper histopathologic diagnosis is imperative, as they may imitate other lesions with different prognosis and management.
KEY WORDS: odontogenic cyst, squamous odontogenic tumor, squamous odontogenic tumor-like proliferations, clinical and histological features
REFERENCES
Anneroth G, Hansen LS: Variations in keratinizing odontogenic cysts and tumors. Oral Surg Oral Med Oral Pathol 54:530–46, 1982
Boni P, Sozzi D, Novelli G, Pagni F, Valente G, Bozzetti A: Primary in- traosseous squamous cell carcinoma of the jaws. 6 new cases, ex- perience and literature comparison. J Oral Maxillofac Surg 74:541- 6, 2016
Cillo JE, Ellis E, Kessler HP: Pericoronal squamous odontogenic tumor associated with an impacted mandibular third molar. A case re- port. J Oral Maxillofac Surg 63:413-6, 2005
Cotten S Jr, Super S, SunderRaj M, Chaudhry A: Multiple nevoid basal cell carcinoma syndrome. J Oral Med 37:69-73, 1982.
Doyle JL, Grodjesk JE, Dolinsky HB, Rafel SS: Squamous odontogenic tumor. Report of three cases. J Oral Surg 35:994-6, 1977
Fay JT, Banner J, Rothouse L, Kolas S, Klinger BJ, Sayers RJ: Squamous odontogenic tumors arising in odontogenic cysts. J Oral Med 36:35–8, 1981
Goldblatt LI, Brannon RB, Ellis GL: Squamous odontogenic tumor. Re- port of five cases and review of the literature. Oral Sur Oral Med Oral Pathol 54:187-96, 1982
Hodgkinson DJ, Woods JE, Dahlin DC, Tolman DE: Keratocysts of the jaw: clinicopathologic study of 79 patients. Cancer 41:803–13, 1978 Huang JW, Luo HY, Li Q, Li TJ: Primary intraosseous squamous cell carcinoma of the jaws. Clinicopathologic presentation and prog-
nostic factors. Arch Pathol Lab Med 133:1834-40, 2009
Ide F, Shimoyama T, Horie N, Shimizu S: Intraosseus squamous cell carcinoma arinsing in association with a squamous odontogenic tumor of the mandible. Oral Oncol 35:431-4, 1999
Karathanasi V, Nikitakis N, Tosios K, Sklavounou A: Clinical and histo- logical types of ameloblastoma. Hellenic Arch Oral Maxillofac Surg 2:91-104, 2010
Leventon GS, Happonen RP, Newland JR: Squamous odontogenic tumor: report of two cases and review of the literature. Am J Surg Pathol 5:671–7, 1981
McClary AC, West RB, Pollack JR, Fischbein NJ, Holsinger CF, Sunwoo J, Colevas AD, Sirjani D: Ameloblastoma. A clinical review and trends in management. Eur Arch Otorhinolaryngol 2015
Nomura T, Monobe H, Tamaruya N, Kishishita S, Saito K, Miyamoto R, Nakao K: Primary intraosseous squamous cell carcinoma of the jaw. Two new cases and review of the literature. Eur Arch Otorhi- nolaryngol 270:375-9, 2013
Oliveira JA, Costa IM, Loyola AM. Squamous odontogenic tumor-like proliferation in residual cyst: case report. Braz Dent J 6:59-64, 1995
Parmar RM, Brannon RB, Fowler CB. Squamous odontogenic tumor- like proliferations in radicular cysts. A clinicopathologic study of forty-two cases. J Endod 37:623-6, 2011
Patron M, Colmenero C, Larrauri J: Glandular odontogenic cyst: clini- copathologic analysis of three cases. Oral Surg Oral Med Oral Pathol 72:71–4, 1991
Philipsen HP, Reichart PA: Squamous odontogenic tumor (SOT). A benign neoplasm of the periodontum. A review of 36 reported cases. J Clin Periodontol 23:922-6, 1996
Pullon PA, Shafer WG, Elzay RP, Kerr DA, Corio RL: Squamous odon- togenic tumor. Report of six cases of a previously undescribed le- sion. Oral Sur Oral Med Oral Pathol 40:616-30, 1975
Sala-Perez S, Marco-Molina V, Gay-Escoda C: Squamous odontogenic tumor-like proliferation in a radicular cyst. A case report. J Clin Exp Dent 5(5):e298-301, 2013
Santos LC, Vilas Bôas DS, Oliveira GQ, Ramos EA, Gurgel CA, dos Santos JN: Histopathological study of radicular cysts diagnosed in a Brazilian population. Braz Dent J 22:449-54, 2011
Shimoyama T, Horie N, Kaneko T, Suzuki T, Tanebayashi Y, Ozawa T, Ide F. Mural squamous odontogenic tumor in a primordial cyst. J Nihon Univ Sch Dent 37:102–4, 1995
Simon JH, Jensen JL: Squamous odontogenic tumor-like proliferation in periapical cysts. J Endod 11:446–8, 1985
Sun ZJ, Wu RY, Cheng N, Zwahlen RA, Zhao YF: Desmoplastic ameloblastoma. A review. Oral Oncol 45:752-9, 2009
Tsianou A, Chrysomali E, Piperi E, Tosios K, Koutlas I, Sklavounou A. Squamous odontogenic tumor (SOT) and SOT-like proliferations: A comparative immunohistochemical study. 10th Biennial Con- gress of the European Association of Oral Medicine, London, Sep- tember, 2010
Unal T, Gomel M, Gunel O: Squamous odontogenic tumor-like islands in a radicular cyst: report of a case. J Oral Maxillofac Surg 45:346– 9, 1987
Waldron CA: Odontogenic cysts and tumors. In: Neville BW, Damm DD, Allen CM, Bouquot JE: Oral and Maxillofacial Pathology. 3rd ed. St. Louis: W.B. Saunders 2012. pp. 702-15
Wright JM: Squamous odontogenic tumor-like proliferations in odontogenic cysts. Oral Surg Oral Med Oral Pathol 47:354–8, 1979
Department of Endodontics (Head: Prof. M. Khabbaz) and Department of Oral Medicine (Head: Prof. A. Sklavounou), Dental School, National and Kapodistrian University of Athens, Greece
Hellenic Archives of Oral & Maxillofacial Surgery (2016) 1, 13-20
SUMMARY: Squamous odontogenic tumor-like prolifer- ations (SOTLPs) are epithelial nests located within the wall of odontogenic cysts and are histologically similar to the squamous odontogenic tumor.
Aim: To present the clinical and microscopical findings of 6 cases of SOTLPs and discuss their differential diagnosis. Materials and Methods: Six cases of SOTLPs in odonto- genic cysts were collected from the archives of the De- partment of Oral Pathology and Medicine, from January 1983 to December 2015.
Results: Five cases occurred in men and one in a woman, with a mean age of 42.5 yrs. Histologically, epithelial is- lands were observed within the connective tissue of the wall of the cysts, which in most cases were infiltrated by inflammatory cells.
Conclusions: SOTLPs constitute a hyperplasia of the ep- ithelial lining of odontogenic cysts and their presence does not affect the biological behavior of the cysts. Proper histopathologic diagnosis is imperative, as they may imitate other lesions with different prognosis and management.
KEY WORDS: odontogenic cyst, squamous odontogenic tumor, squamous odontogenic tumor-like proliferations, clinical and histological features
REFERENCES
Anneroth G, Hansen LS: Variations in keratinizing odontogenic cysts and tumors. Oral Surg Oral Med Oral Pathol 54:530–46, 1982
Boni P, Sozzi D, Novelli G, Pagni F, Valente G, Bozzetti A: Primary in- traosseous squamous cell carcinoma of the jaws. 6 new cases, ex- perience and literature comparison. J Oral Maxillofac Surg 74:541- 6, 2016
Cillo JE, Ellis E, Kessler HP: Pericoronal squamous odontogenic tumor associated with an impacted mandibular third molar. A case re- port. J Oral Maxillofac Surg 63:413-6, 2005
Cotten S Jr, Super S, SunderRaj M, Chaudhry A: Multiple nevoid basal cell carcinoma syndrome. J Oral Med 37:69-73, 1982.
Doyle JL, Grodjesk JE, Dolinsky HB, Rafel SS: Squamous odontogenic tumor. Report of three cases. J Oral Surg 35:994-6, 1977
Fay JT, Banner J, Rothouse L, Kolas S, Klinger BJ, Sayers RJ: Squamous odontogenic tumors arising in odontogenic cysts. J Oral Med 36:35–8, 1981
Goldblatt LI, Brannon RB, Ellis GL: Squamous odontogenic tumor. Re- port of five cases and review of the literature. Oral Sur Oral Med Oral Pathol 54:187-96, 1982
Hodgkinson DJ, Woods JE, Dahlin DC, Tolman DE: Keratocysts of the jaw: clinicopathologic study of 79 patients. Cancer 41:803–13, 1978 Huang JW, Luo HY, Li Q, Li TJ: Primary intraosseous squamous cell carcinoma of the jaws. Clinicopathologic presentation and prog-
nostic factors. Arch Pathol Lab Med 133:1834-40, 2009
Ide F, Shimoyama T, Horie N, Shimizu S: Intraosseus squamous cell carcinoma arinsing in association with a squamous odontogenic tumor of the mandible. Oral Oncol 35:431-4, 1999
Karathanasi V, Nikitakis N, Tosios K, Sklavounou A: Clinical and histo- logical types of ameloblastoma. Hellenic Arch Oral Maxillofac Surg 2:91-104, 2010
Leventon GS, Happonen RP, Newland JR: Squamous odontogenic tumor: report of two cases and review of the literature. Am J Surg Pathol 5:671–7, 1981
McClary AC, West RB, Pollack JR, Fischbein NJ, Holsinger CF, Sunwoo J, Colevas AD, Sirjani D: Ameloblastoma. A clinical review and trends in management. Eur Arch Otorhinolaryngol 2015
Nomura T, Monobe H, Tamaruya N, Kishishita S, Saito K, Miyamoto R, Nakao K: Primary intraosseous squamous cell carcinoma of the jaw. Two new cases and review of the literature. Eur Arch Otorhi- nolaryngol 270:375-9, 2013
Oliveira JA, Costa IM, Loyola AM. Squamous odontogenic tumor-like proliferation in residual cyst: case report. Braz Dent J 6:59-64, 1995
Parmar RM, Brannon RB, Fowler CB. Squamous odontogenic tumor- like proliferations in radicular cysts. A clinicopathologic study of forty-two cases. J Endod 37:623-6, 2011
Patron M, Colmenero C, Larrauri J: Glandular odontogenic cyst: clini- copathologic analysis of three cases. Oral Surg Oral Med Oral Pathol 72:71–4, 1991
Philipsen HP, Reichart PA: Squamous odontogenic tumor (SOT). A benign neoplasm of the periodontum. A review of 36 reported cases. J Clin Periodontol 23:922-6, 1996
Pullon PA, Shafer WG, Elzay RP, Kerr DA, Corio RL: Squamous odon- togenic tumor. Report of six cases of a previously undescribed le- sion. Oral Sur Oral Med Oral Pathol 40:616-30, 1975
Sala-Perez S, Marco-Molina V, Gay-Escoda C: Squamous odontogenic tumor-like proliferation in a radicular cyst. A case report. J Clin Exp Dent 5(5):e298-301, 2013
Santos LC, Vilas Bôas DS, Oliveira GQ, Ramos EA, Gurgel CA, dos Santos JN: Histopathological study of radicular cysts diagnosed in a Brazilian population. Braz Dent J 22:449-54, 2011
Shimoyama T, Horie N, Kaneko T, Suzuki T, Tanebayashi Y, Ozawa T, Ide F. Mural squamous odontogenic tumor in a primordial cyst. J Nihon Univ Sch Dent 37:102–4, 1995
Simon JH, Jensen JL: Squamous odontogenic tumor-like proliferation in periapical cysts. J Endod 11:446–8, 1985
Sun ZJ, Wu RY, Cheng N, Zwahlen RA, Zhao YF: Desmoplastic ameloblastoma. A review. Oral Oncol 45:752-9, 2009
Tsianou A, Chrysomali E, Piperi E, Tosios K, Koutlas I, Sklavounou A. Squamous odontogenic tumor (SOT) and SOT-like proliferations: A comparative immunohistochemical study. 10th Biennial Con- gress of the European Association of Oral Medicine, London, Sep- tember, 2010
Unal T, Gomel M, Gunel O: Squamous odontogenic tumor-like islands in a radicular cyst: report of a case. J Oral Maxillofac Surg 45:346– 9, 1987
Waldron CA: Odontogenic cysts and tumors. In: Neville BW, Damm DD, Allen CM, Bouquot JE: Oral and Maxillofacial Pathology. 3rd ed. St. Louis: W.B. Saunders 2012. pp. 702-15
Wright JM: Squamous odontogenic tumor-like proliferations in odontogenic cysts. Oral Surg Oral Med Oral Pathol 47:354–8, 1979
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